Entity Details

Primary name SRBP2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ3U1N2
EntryNameSRBP2_MOUSE
FullNameSterol regulatory element-binding protein 2
TaxID10090
Evidenceevidence at protein level
Length1130
SequenceStatuscomplete
DateCreated2008-02-05
DateModified2021-06-02

Ontological Relatives

GenesSrebf2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008022 protein C-terminus binding
GO:0008203 cholesterol metabolic process
GO:0008593 regulation of Notch signaling pathway
GO:0009267 cellular response to starvation
GO:0009725 response to hormone
GO:0010886 positive regulation of cholesterol storage
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0032933 SREBP signaling pathway
GO:0032937 SREBP-SCAP-Insig complex
GO:0042632 cholesterol homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043565 sequence-specific DNA binding
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090370 negative regulation of cholesterol efflux
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Golgi apparatus membrane
Nucleus

Domains

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DomainNameCategoryType
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions