Entity Details

Primary name NTRK1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ3UFB7
EntryNameNTRK1_MOUSE
FullNameHigh affinity nerve growth factor receptor
TaxID10090
Evidenceevidence at protein level
Length799
SequenceStatuscomplete
DateCreated2007-02-20
DateModified2021-06-02

Ontological Relatives

GenesNtrk1

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005030 neurotrophin receptor activity
GO:0005166 neurotrophin p75 receptor binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007568 aging
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0008285 negative regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009986 cell surface
GO:0010465 nerve growth factor receptor activity
GO:0010623 programmed cell death involved in cell development
GO:0010976 positive regulation of neuron projection development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019233 sensory perception of pain
GO:0019900 kinase binding
GO:0021553 olfactory nerve development
GO:0030183 B cell differentiation
GO:0030424 axon
GO:0030425 dendrite
GO:0031175 neuron projection development
GO:0031410 cytoplasmic vesicle
GO:0031667 response to nutrient levels
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032991 protein-containing complex
GO:0033674 positive regulation of kinase activity
GO:0035094 response to nicotine
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038180 nerve growth factor signaling pathway
GO:0042490 mechanoreceptor differentiation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043068 positive regulation of programmed cell death
GO:0043121 neurotrophin binding
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045766 positive regulation of angiogenesis
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048406 nerve growth factor binding
GO:0048485 sympathetic nervous system development
GO:0048666 neuron development
GO:0048678 response to axon injury
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051599 response to hydrostatic pressure
GO:0051602 response to electrical stimulus
GO:0051896 regulation of protein kinase B signaling
GO:0051965 positive regulation of synapse assembly
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0060009 Sertoli cell development
GO:0060384 innervation
GO:0060385 axonogenesis involved in innervation
GO:0061368 behavioral response to formalin induced pain
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071316 cellular response to nicotine
GO:0071363 cellular response to growth factor stimulus
GO:1901215 negative regulation of neuron death
GO:1990090 cellular response to nerve growth factor stimulus

Subcellular Location

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Subcellular Location
Cell membrane
Early endosome membrane
Late endosome membrane
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1FamilyFamily
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020777 Tyrosine-protein kinase, neurotrophic receptorFamilyFamily
IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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