Entity Details

Primary name AAPK1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ5EG47
EntryNameAAPK1_MOUSE
FullName5'-AMP-activated protein kinase catalytic subunit alpha-1
TaxID10090
Evidenceevidence at protein level
Length559
SequenceStatuscomplete
DateCreated2005-09-13
DateModified2021-06-02

Ontological Relatives

GenesPrkaa1

GO terms

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GOName
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0006914 autophagy
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0008610 lipid biosynthetic process
GO:0009411 response to UV
GO:0009631 cold acclimation
GO:0010332 response to gamma radiation
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014823 response to activity
GO:0015721 bile acid and bile salt transport
GO:0016055 Wnt signaling pathway
GO:0016324 apical plasma membrane
GO:0016607 nuclear speck
GO:0019395 fatty acid oxidation
GO:0019900 kinase binding
GO:0030424 axon
GO:0030425 dendrite
GO:0031000 response to caffeine
GO:0031588 nucleotide-activated protein kinase complex
GO:0031669 cellular response to nutrient levels
GO:0032007 negative regulation of TOR signaling
GO:0032991 protein-containing complex
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0034599 cellular response to oxidative stress
GO:0035174 histone serine kinase activity
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0038183 bile acid signaling pathway
GO:0042149 cellular response to glucose starvation
GO:0042542 response to hydrogen peroxide
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045821 positive regulation of glycolytic process
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0048511 rhythmic process
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0050321 tau-protein kinase activity
GO:0050405 [acetyl-CoA carboxylase] kinase activity
GO:0050995 negative regulation of lipid catabolic process
GO:0055089 fatty acid homeostasis
GO:0060627 regulation of vesicle-mediated transport
GO:0061744 motor behavior
GO:0061762 CAMKK-AMPK signaling cascade
GO:0062028 regulation of stress granule assembly
GO:0070050 neuron cellular homeostasis
GO:0070301 cellular response to hydrogen peroxide
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071277 cellular response to calcium ion
GO:0071333 cellular response to glucose stimulus
GO:0071361 cellular response to ethanol
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071456 cellular response to hypoxia
GO:0097009 energy homeostasis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0120188 regulation of bile acid secretion
GO:1901563 response to camptothecin
GO:1903109 positive regulation of mitochondrial transcription
GO:1903829 positive regulation of cellular protein localization
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904428 negative regulation of tubulin deacetylation
GO:1904486 response to 17alpha-ethynylestradiol
GO:2000758 positive regulation of peptidyl-lysine acetylation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028375 KA1 domain/Ssp2, C-terminalFamilyHomologous superfamily
IPR028797 PRKAA1, UBA-like autoinhibitory domainDomainDomain
IPR032270 AMPK, C-terminal adenylate sensor domainDomainDomain
IPR039137 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminalDomainDomain

Diseases

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