Entity Details

Primary name SIN3A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60520
EntryNameSIN3A_MOUSE
FullNamePaired amphipathic helix protein Sin3a
TaxID10090
Evidenceevidence at protein level
Length1274
SequenceStatuscomplete
DateCreated2003-09-19
DateModified2021-06-02

Ontological Relatives

GenesSin3a

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000776 kinetochore
GO:0000785 chromatin
GO:0001701 in utero embryonic development
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0006260 DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0006476 protein deacetylation
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0010243 response to organonitrogen compound
GO:0010817 regulation of hormone levels
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016575 histone deacetylation
GO:0016580 Sin3 complex
GO:0017053 transcription repressor complex
GO:0021895 cerebral cortex neuron differentiation
GO:0030516 regulation of axon extension
GO:0031937 positive regulation of chromatin silencing
GO:0032991 protein-containing complex
GO:0034613 cellular protein localization
GO:0042754 negative regulation of circadian rhythm
GO:0043066 negative regulation of apoptotic process
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0044877 protein-containing complex binding
GO:0045666 positive regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0051595 response to methylglyoxal
GO:0071333 cellular response to glucose stimulus
GO:0140416 transcription regulator inhibitor activity
GO:1900181 negative regulation of protein localization to nucleus
GO:1901675 negative regulation of histone H3-K27 acetylation
GO:1903351 cellular response to dopamine
GO:2000678 negative regulation of transcription regulatory region DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003822 Paired amphipathic helixRepeatRepeat
IPR013194 Histone deacetylase interacting domainDomainDomain
IPR031693 Sin3, C-terminalDomainDomain
IPR036600 Paired amphipathic helix superfamilyFamilyHomologous superfamily
IPR037969 Transcriptional regulatory protein Sin3aFamilyFamily
IPR039774 Transcriptional regulatory protein Sin3-likeFamilyFamily

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
SIN3A_MOUSESDS3_MOUSEBioGRID, IntAct11909966 15489224 details
SIN3A_MOUSESAP30_MOUSEIntAct9702189 details
SIN3A_MOUSESAP25_MOUSEIntAct16449650 details
SIN3A_MOUSEHD_HUMANBioGRID10823891 details
SIN3A_MOUSEMAD1_HUMANBioGRID10551834 11101889 details
SIN3A_MOUSEREST_HUMANBioGRID10570134 details
SIN3A_MOUSECSN2_HUMANBioGRID10207062 details
SIN3A_MOUSESAP18_HUMANBioGRID11960000 details
SIN3A_MOUSEMNT_HUMANBioGRID10918583 details
SIN3A_MOUSEADDA_MOUSEBioGRID17074803 details
SIN3A_MOUSEP53_MOUSEBioGRID20211142 details
SIN3A_MOUSEKLF13_MOUSEBioGRID11477107 details
SIN3A_MOUSEKLF1_HUMANBioGRID11287616 details
SIN3A_MOUSEELK1_HUMANBioGRID11283259 details
SIN3A_MOUSESFPQ_HUMANBioGRID11259580 details
SIN3A_MOUSESMAD3_HUMANBioGRID10575014 details
SIN3A_MOUSESKIL_HUMANBioGRID10049357 details
SIN3A_MOUSERB_HUMANBioGRID9988677 details
SIN3A_MOUSEDDX20_MOUSEBioGRID12007404 details
SIN3A_MOUSECEBPB_MOUSEBioGRID21521687 details
SIN3A_MOUSEDACH1_MOUSEIntAct12130660 details
SIN3A_MOUSENCOR1_MOUSEIntAct9702189 details
SIN3A_MOUSEHDAC2_MOUSEBioGRID, DIP, IntAct, MINT15696166 16109738 18454139 19424149 20404188 24240174 details
SIN3A_MOUSEARI1A_MOUSEBioGRID, MINT17255939 details
SIN3A_MOUSEPA2G4_HUMANIntAct16254079 details
SIN3A_MOUSEHDAC9_HUMANUniProt12590135 details
SIN3A_MOUSESOX2_MOUSEBioGRID, IntAct19139101 31077711 details
SIN3A_MOUSEHDAC1_MOUSEBioGRID, DIP, MINT10409740 10688671 11302704 16103876 16109738 19424149 20404188 21448134 21454521 24240174 details
SIN3A_MOUSETET1_MOUSEUniProt21490601 details
SIN3A_MOUSENANOG_MOUSEBioGRID, MINT18454139 23892456 details
SIN3A_MOUSEMYC_HUMANIntAct24951594 details
SIN3A_MOUSEMECP2_MOUSEBioGRID, DIP, MINT19602036 22119903 23770565 details
SIN3A_MOUSEIKZF1_HUMANBioGRID10357820 details
SIN3A_MOUSETAL1_MOUSEBioGRID10688671 11118214 details
SIN3A_MOUSESUFU_MOUSEBioGRID11960000 details
SIN3A_MOUSEGLI1_HUMANBioGRID11960000 details
SIN3A_MOUSESMAD4_MOUSEBioGRID17226765 details
SIN3A_MOUSEP66A_MOUSEBioGRID18454139 details
SIN3A_MOUSESNAI1_HUMANBioGRID14673164 28892081 details
SIN3A_MOUSESNAI2_HUMANBioGRID14673164 details
SIN3A_MOUSESNAI3_HUMANBioGRID14673164 details
SIN3A_MOUSESP3_MOUSEBioGRID16109738 details
SIN3A_MOUSEMNT_MOUSEBioGRID16103876 details
SIN3A_MOUSESIN3B_MOUSEBioGRID16103876 details
SIN3A_MOUSEP53_HUMANBioGRID11313951 details
SIN3A_MOUSETBP_HUMANBioGRID11313951 details
SIN3A_MOUSESPI1_MOUSEBioGRID21518930 details
SIN3A_MOUSEGON4L_MOUSEBioGRID21454521 details
SIN3A_MOUSETYY1_MOUSEBioGRID21454521 details
SIN3A_MOUSEAPEX1_MOUSEBioGRID22441348 details
SIN3A_MOUSEPER2_MOUSEBioGRID21680841 details
SIN3A_MOUSESFPQ_MOUSEBioGRID21680841 details
SIN3A_MOUSEPER1_MOUSEBioGRID21680841 details
SIN3A_MOUSEETV6_MOUSEBioGRID12527908 details
SIN3A_MOUSEKLF11_MOUSEBioGRID15300592 details
SIN3A_MOUSETET2_MOUSEBioGRID21490601 details
SIN3A_MOUSELMBL2_MOUSEBioGRID22770845 details