Entity Details

Primary name SRC8_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60598
EntryNameSRC8_MOUSE
FullNameSrc substrate cortactin
TaxID10090
Evidenceevidence at protein level
Length546
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCttn

GO terms

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GOName
GO:0001726 ruffle
GO:0002102 podosome
GO:0005522 profilin binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0006886 intracellular protein transport
GO:0006898 receptor-mediated endocytosis
GO:0006930 substrate-dependent cell migration, cell extension
GO:0008076 voltage-gated potassium channel complex
GO:0030027 lamellipodium
GO:0030041 actin filament polymerization
GO:0030054 cell junction
GO:0030427 site of polarized growth
GO:0030516 regulation of axon extension
GO:0030833 regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0030863 cortical cytoskeleton
GO:0030864 cortical actin cytoskeleton
GO:0031532 actin cytoskeleton reorganization
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0045987 positive regulation of smooth muscle contraction
GO:0048041 focal adhesion assembly
GO:0048812 neuron projection morphogenesis
GO:0048870 cell motility
GO:0050921 positive regulation of chemotaxis
GO:0051015 actin filament binding
GO:0060491 regulation of cell projection assembly
GO:0070064 proline-rich region binding
GO:0071933 Arp2/3 complex binding
GO:0097062 dendritic spine maintenance
GO:0097581 lamellipodium organization
GO:0098871 postsynaptic actin cytoskeleton
GO:0098885 modification of postsynaptic actin cytoskeleton
GO:0098978 glutamatergic synapse
GO:1903146 regulation of autophagy of mitochondrion
GO:1990023 mitotic spindle midzone
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR003134 Hs1/CortactinRepeatRepeat
IPR015503 CortactinFamilyFamily
IPR035716 Cortactin, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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