Entity Details

Primary name TIAM1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60610
EntryNameTIAM1_MOUSE
FullNameRho guanine nucleotide exchange factor TIAM1
TaxID10090
Evidenceevidence at protein level
Length1591
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000242 pericentriolar material
GO:0003300 cardiac muscle hypertrophy
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005543 phospholipid binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006915 apoptotic process
GO:0007160 cell-matrix adhesion
GO:0007264 small GTPase mediated signal transduction
GO:0008017 microtubule binding
GO:0008284 positive regulation of cell population proliferation
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010976 positive regulation of neuron projection development
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016477 cell migration
GO:0016601 Rac protein signal transduction
GO:0019900 kinase binding
GO:0030335 positive regulation of cell migration
GO:0030971 receptor tyrosine kinase binding
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0032092 positive regulation of protein binding
GO:0032587 ruffle membrane
GO:0034622 cellular protein-containing complex assembly
GO:0036477 somatodendritic compartment
GO:0043025 neuronal cell body
GO:0043087 regulation of GTPase activity
GO:0043197 dendritic spine
GO:0043507 positive regulation of JUN kinase activity
GO:0044291 cell-cell contact zone
GO:0044295 axonal growth cone
GO:0044304 main axon
GO:0045202 synapse
GO:0046875 ephrin receptor binding
GO:0048013 ephrin receptor signaling pathway
GO:0050772 positive regulation of axonogenesis
GO:0060091 kinocilium
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0072657 protein localization to membrane
GO:0090630 activation of GTPase activity
GO:0098978 glutamatergic synapse
GO:0098989 NMDA selective glutamate receptor signaling pathway
GO:0099147 extrinsic component of postsynaptic density membrane
GO:1904268 positive regulation of Schwann cell chemotaxis
GO:1904338 regulation of dopaminergic neuron differentiation
GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
GO:1990138 neuron projection extension
GO:2000050 regulation of non-canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001478 PDZ domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR003116 Raf-like Ras-bindingDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR033360 T-lymphoma invasion and metastasis-inducing protein 1FamilyFamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR040655 TIAM1, CC-Ex domainDomainDomain
IPR043537 Tiam1/Tiam2/Protein still lifeFamilyFamily

Diseases

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