Entity Details

Primary name GRB2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60631
EntryNameGRB2_MOUSE
FullNameGrowth factor receptor-bound protein 2
TaxID10090
Evidenceevidence at protein level
Length217
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesGrb2

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0005154 epidermal growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007568 aging
GO:0008180 COP9 signalosome
GO:0008286 insulin receptor signaling pathway
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0030154 cell differentiation
GO:0030674 protein-macromolecule adaptor activity
GO:0030838 positive regulation of actin filament polymerization
GO:0031532 actin cytoskeleton reorganization
GO:0031623 receptor internalization
GO:0032991 protein-containing complex
GO:0042770 signal transduction in response to DNA damage
GO:0042802 identical protein binding
GO:0043408 regulation of MAPK cascade
GO:0043560 insulin receptor substrate binding
GO:0044877 protein-containing complex binding
GO:0046875 ephrin receptor binding
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0051219 phosphoprotein binding
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0070436 Grb2-EGFR complex
GO:0071479 cellular response to ionizing radiation
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome
Golgi apparatus
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR035641 GRB2, N-terminal SH3 domainDomainDomain
IPR035643 GRB2, C-terminal SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
GRB2_MOUSEADA12_MOUSEMINT11127814 details
GRB2_MOUSEUBP8_MOUSEMINT10982817 details
GRB2_MOUSESNTA1_MOUSEMINT11551227 details
GRB2_MOUSEEPHB1_HUMANIntAct8798570 details
GRB2_MOUSECD22_MOUSEBioGRID, IntAct, MINT10373493 11551923 details
GRB2_MOUSESHC1_MOUSEBioGRID, IntAct, MINT10362356 10748054 10995764 11259577 17673906 18273058 20697350 23452850 7529871 7535773 7538132 7689150 8479540 9013573 details
GRB2_MOUSEGAB1_MOUSEBioGRID, IntAct, MINT10871282 11445578 11896055 15102471 23452850 25159185 32325033 details
GRB2_MOUSESOS2_MOUSEIntAct15102471 15953601 23452850 details
GRB2_MOUSEERRFI_MOUSEIntAct15102471 details
GRB2_MOUSEGAB2_MOUSEIntAct15102471 details
GRB2_MOUSEDYN2_MOUSEBioGRID, IntAct15102471 23452850 32325033 details
GRB2_MOUSECD2AP_MOUSEIntAct15102471 details
GRB2_MOUSEVAV2_MOUSEIntAct15102471 details
GRB2_MOUSEKHDR1_MOUSEIntAct, UniProt10077576 15102471 details
GRB2_MOUSEUCK2_MOUSEIntAct15102471 details
GRB2_MOUSEBCAP_MOUSEIntAct15102471 details
GRB2_MOUSEBTK_MOUSEIntAct15102471 details
GRB2_MOUSEPDC6I_MOUSEIntAct15102471 details
GRB2_MOUSESH3K1_MOUSEBioGRID, IntAct15102471 32325033 details
GRB2_MOUSEVAV_MOUSEIntAct15102471 details
GRB2_MOUSEKI26A_MOUSEIntAct19914172 details
GRB2_MOUSEPRIO_MOUSEBioGRID, MINT11571277 15301538 details
GRB2_MOUSETIE2_MOUSEBioGRID, MINT10521483 details
GRB2_MOUSEPTN11_MOUSEBioGRID, IntAct, MINT10995764 11684012 23452850 details
GRB2_MOUSEPTPRA_MOUSEIntAct, MINT23452850 7518772 details
GRB2_MOUSEEGFR_MOUSEBioGRID, MINT11896055 17372273 20676128 23027125 23799367 7689150 8264620 9363897 details
GRB2_MOUSELCP2_MOUSEBioGRID, IntAct24584089 7706237 details
GRB2_MOUSEP85A_MOUSEBioGRID10995764 32325033 9174058 details
GRB2_MOUSEKIT_MOUSEBioGRID10679268 details
GRB2_MOUSEA4_MOUSEBioGRID27325702 details
GRB2_MOUSEBTLA_MOUSEBioGRID16725108 details
GRB2_MOUSEPGFRB_MOUSEBioGRID8264620 details
GRB2_MOUSESYPH_MOUSEBioGRID8264620 details
GRB2_MOUSEOTUD4_HUMANBioGRID31138677 details
GRB2_MOUSEPLCG1_MOUSEBioGRID, InnateDB, IntAct15953601 22561606 32325033 details
GRB2_MOUSECBL_MOUSEBioGRID, IntAct17372273 21703542 21725061 23452850 27474268 32325033 7657591 8635998 9174058 details
GRB2_MOUSEEPHB2_MOUSEIntAct16298995 details
GRB2_MOUSEFAK1_MOUSEIntAct, MINT16298995 7997267 details
GRB2_MOUSEMED28_HUMANIntAct15467741 details
GRB2_MOUSEIRS1_HUMANBioGRID, IntAct12679424 8662827 details
GRB2_MOUSESHIP1_MOUSEIntAct10068665 details
GRB2_MOUSESOS1_MOUSEBioGRID, IntAct, MINT, UniProt10373493 23452850 32325033 8479540 9569023 details
GRB2_MOUSEEGFR_HUMANMINT8940013 details
GRB2_MOUSESHC1_HUMANMINT8940013 details
GRB2_MOUSEBLNK_HUMANMINT16912232 details
GRB2_MOUSEFRS2_MOUSEBioGRID, IntAct, MINT15870281 23452850 9182757 details
GRB2_MOUSEKPCA_MOUSEMINT12881490 details
GRB2_MOUSELAT_MOUSEInnateDB, IntAct, MINT21487392 22561606 24584089 details
GRB2_MOUSEDAB2_MOUSEUniProt9569023 details
GRB2_MOUSETHMS1_MOUSEDIP, InnateDB19805304 22561606 details
GRB2_MOUSERAB13_MOUSEUniProt21543326 details
GRB2_MOUSEKHDR2_MOUSEUniProt10077576 details
GRB2_MOUSEAJUBA_MOUSEDIP15630473 details
GRB2_MOUSEIRS2_MOUSEIntAct11259577 details
GRB2_MOUSEIRS1_MOUSEIntAct11259577 details
GRB2_MOUSECD28_HUMANBioGRID9694876 details
GRB2_MOUSEDVL2_MOUSEBioGRID19920076 details
GRB2_MOUSEA4_HUMANBioGRID17384289 details
GRB2_MOUSESH2B2_MOUSEBioGRID9989826 details
GRB2_MOUSECSF1R_MOUSEBioGRID10330148 details
GRB2_MOUSEBCR_MOUSEBioGRID20697350 details
GRB2_MOUSEYBOX1_MOUSEBioGRID20697350 details
GRB2_MOUSEMERL_MOUSEBioGRID16405865 details
GRB2_MOUSESPY1_MOUSEBioGRID11585837 16339969 details
GRB2_MOUSESPY2_MOUSEBioGRID11585837 16339969 details
GRB2_MOUSESHAN3_MOUSEBioGRID15569713 details
GRB2_MOUSESPRY3_MOUSEBioGRID16339969 details
GRB2_MOUSESPY4_MOUSEBioGRID16339969 details
GRB2_MOUSEDOK3_MOUSEBioGRID26548852 details
GRB2_MOUSEVGFR2_MOUSEBioGRID16966330 details
GRB2_MOUSEFRS2_HUMANBioGRID25159185 details
GRB2_MOUSEUFO_MOUSEBioGRID18346204 details
GRB2_MOUSETNR16_MOUSEBioGRID9368064 details