Entity Details

Primary name NR1H4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60641
EntryNameNR1H4_MOUSE
FullNameBile acid receptor
TaxID10090
Evidenceevidence at protein level
Length488
SequenceStatuscomplete
DateCreated2002-05-27
DateModified2021-06-02

Ontological Relatives

GenesNr1h4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001678 cellular glucose homeostasis
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0006109 regulation of carbohydrate metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006954 inflammatory response
GO:0007043 cell-cell junction assembly
GO:0007219 Notch signaling pathway
GO:0008206 bile acid metabolic process
GO:0008270 zinc ion binding
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010868 negative regulation of triglyceride biosynthetic process
GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
GO:0010988 regulation of low-density lipoprotein particle clearance
GO:0015721 bile acid and bile salt transport
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0032052 bile acid binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032692 negative regulation of interleukin-1 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032740 positive regulation of interleukin-17 production
GO:0032966 negative regulation of collagen biosynthetic process
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034255 regulation of urea metabolic process
GO:0034971 histone H3-R17 methylation
GO:0035356 cellular triglyceride homeostasis
GO:0035690 cellular response to drug
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0038181 bile acid receptor activity
GO:0038183 bile acid signaling pathway
GO:0038185 intracellular bile acid receptor signaling pathway
GO:0042277 peptide binding
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0043565 sequence-specific DNA binding
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046965 retinoid X receptor binding
GO:0050728 negative regulation of inflammatory response
GO:0055089 fatty acid homeostasis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070328 triglyceride homeostasis
GO:0071222 cellular response to lipopolysaccharide
GO:0071398 cellular response to fatty acid
GO:0071417 cellular response to organonitrogen compound
GO:0071638 negative regulation of monocyte chemotactic protein-1 production
GO:0071873 response to norepinephrine
GO:1902122 chenodeoxycholic acid binding
GO:1903413 cellular response to bile acid
GO:1904179 positive regulation of adipose tissue development
GO:1905695 positive regulation of phosphatidic acid biosynthetic process
GO:2000213 positive regulation of glutamate metabolic process
GO:2001250 positive regulation of ammonia assimilation cycle

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR001728 Thyroid hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR044114 Bile acid receptor, ligand binding domainDomainDomain

Diseases

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