Entity Details

Primary name CRFR2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60748
EntryNameCRFR2_MOUSE
FullNameCorticotropin-releasing factor receptor 2
TaxID10090
Evidenceevidence at protein level
Length411
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCrhr2

GO terms

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GOName
GO:0005179 hormone activity
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0007015 actin filament organization
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0008528 G protein-coupled peptide receptor activity
GO:0009986 cell surface
GO:0010460 positive regulation of heart rate
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010700 negative regulation of norepinephrine secretion
GO:0014064 positive regulation of serotonin secretion
GO:0015056 corticotrophin-releasing factor receptor activity
GO:0016021 integral component of membrane
GO:0016525 negative regulation of angiogenesis
GO:0017046 peptide hormone binding
GO:0019233 sensory perception of pain
GO:0030424 axon
GO:0030425 dendrite
GO:0030855 epithelial cell differentiation
GO:0032755 positive regulation of interleukin-6 production
GO:0032811 negative regulation of epinephrine secretion
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033685 negative regulation of luteinizing hormone secretion
GO:0035482 gastric motility
GO:0042423 catecholamine biosynthetic process
GO:0043025 neuronal cell body
GO:0043196 varicosity
GO:0043204 perikaryon
GO:0043404 corticotropin-releasing hormone receptor activity
GO:0043679 axon terminus
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045777 positive regulation of blood pressure
GO:0046882 negative regulation of follicle-stimulating hormone secretion
GO:0048630 skeletal muscle tissue growth
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060291 long-term synaptic potentiation
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070852 cell body fiber
GO:0090281 negative regulation of calcium ion import
GO:2000252 negative regulation of feeding behavior
GO:2000293 negative regulation of defecation
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000832 GPCR, family 2, secretin-likeFamilyFamily
IPR001879 GPCR, family 2, extracellular hormone receptor domainDomainDomain
IPR003051 GPCR, family 2, corticotropin releasing factor receptorFamilyFamily
IPR003053 GPCR, family 2, corticotropin releasing factor receptor, type 2FamilyFamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR017983 GPCR, family 2, secretin-like, conserved siteSiteConserved site
IPR036445 GPCR family 2, extracellular hormone receptor domain superfamilyFamilyHomologous superfamily

Diseases

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