Entity Details

Primary name EPHA1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60750
EntryNameEPHA1_MOUSE
FullNameEphrin type-A receptor 1
TaxID10090
Evidenceevidence at protein level
Length977
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesEpha1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001954 positive regulation of cell-matrix adhesion
GO:0001968 fibronectin binding
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006469 negative regulation of protein kinase activity
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0008284 positive regulation of cell population proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019901 protein kinase binding
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0033674 positive regulation of kinase activity
GO:0034446 substrate adhesion-dependent cell spreading
GO:0043005 neuron projection
GO:0043087 regulation of GTPase activity
GO:0043235 receptor complex
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0051496 positive regulation of stress fiber assembly
GO:0090630 activation of GTPase activity

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034251 Ephrin type-A receptor 1, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink