Entity Details

Primary name IGF1R_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60751
EntryNameIGF1R_MOUSE
FullNameInsulin-like growth factor 1 receptor
TaxID10090
Evidenceevidence at protein level
Length1373
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesIgf1r

GO terms

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GOName
GO:0001965 G-protein alpha-subunit binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005009 insulin-activated receptor activity
GO:0005010 insulin-like growth factor-activated receptor activity
GO:0005158 insulin receptor binding
GO:0005198 structural molecule activity
GO:0005520 insulin-like growth factor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008544 epidermis development
GO:0009887 animal organ morphogenesis
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0021549 cerebellum development
GO:0030010 establishment of cell polarity
GO:0030238 male sex determination
GO:0030315 T-tubule
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030879 mammary gland development
GO:0031017 exocrine pancreas development
GO:0031175 neuron projection development
GO:0031994 insulin-like growth factor I binding
GO:0032467 positive regulation of cytokinesis
GO:0032869 cellular response to insulin stimulus
GO:0033674 positive regulation of kinase activity
GO:0033690 positive regulation of osteoblast proliferation
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0043243 positive regulation of protein-containing complex disassembly
GO:0043409 negative regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0044849 estrous cycle
GO:0044877 protein-containing complex binding
GO:0045056 transcytosis
GO:0045471 response to ethanol
GO:0045840 positive regulation of mitotic nuclear division
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046328 regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048639 positive regulation of developmental growth
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048680 positive regulation of axon regeneration
GO:0051054 positive regulation of DNA metabolic process
GO:0051389 obsolete inactivation of MAPKK activity
GO:0051446 positive regulation of meiotic cell cycle
GO:0051897 positive regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
GO:0060740 prostate gland epithelium morphogenesis
GO:0071333 cellular response to glucose stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090031 positive regulation of steroid hormone biosynthetic process
GO:0097062 dendritic spine maintenance
GO:0097242 amyloid-beta clearance
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0140318 protein transporter activity
GO:1902065 response to L-glutamate
GO:1902911 protein kinase complex
GO:1903944 negative regulation of hepatocyte apoptotic process
GO:1904193 negative regulation of cholangiocyte apoptotic process
GO:1904646 cellular response to amyloid-beta
GO:1990314 cellular response to insulin-like growth factor stimulus

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016246 Tyrosine-protein kinase, insulin-like receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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