Entity Details

Primary name TRAF3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60803
EntryNameTRAF3_MOUSE
FullNameTNF receptor-associated factor 3
TaxID10090
Evidenceevidence at protein level
Length567
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesTraf3

GO terms

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GOName
GO:0001817 regulation of cytokine production
GO:0002224 toll-like receptor signaling pathway
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005768 endosome
GO:0006915 apoptotic process
GO:0008063 Toll signaling pathway
GO:0008270 zinc ion binding
GO:0009898 cytoplasmic side of plasma membrane
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030162 regulation of proteolysis
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032648 regulation of interferon-beta production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035631 CD40 receptor complex
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0050688 regulation of defense response to virus
GO:0070534 protein K63-linked ubiquitination

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome

Domains

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DomainNameCategoryType
IPR001293 Zinc finger, TRAF-typeDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR002083 MATH/TRAF domainDomainDomain
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR012227 TNF receptor-associated factor TRAF, metazoaFamilyFamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027128 TNF receptor-associated factor 3FamilyFamily
IPR037304 TRAF3, MATH domainDomainDomain
IPR043211 TNF receptor-associated factor TRAFFamilyFamily

Diseases

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Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
TRAF3_MOUSETNR4_MOUSEIntAct9418902 details
TRAF3_MOUSETNR9_MOUSEIntAct9418902 details
TRAF3_MOUSETNR11_MOUSEIntAct15102471 details
TRAF3_MOUSEPTN22_HUMANIntAct23871208 details
TRAF3_MOUSETCAM1_MOUSEBioGRID, DIP16306936 16306937 19898473 details
TRAF3_MOUSEMYD88_MOUSEBioGRID, DIP16306937 19898473 22011580 details
TRAF3_MOUSEBIRC3_MOUSEBioGRID18635759 details
TRAF3_MOUSEMYSM1_MOUSEBioGRID26474655 details
TRAF3_MOUSEMAVS_MOUSEBioGRID, MINT16858409 25847972 32324863 details
TRAF3_MOUSEUBB_MOUSEDIP, IntAct18083102 23334419 details
TRAF3_MOUSEUBC_MOUSEDIP, IntAct18083102 23334419 details
TRAF3_MOUSERS27A_MOUSEDIP, IntAct18083102 23334419 details
TRAF3_MOUSERL40_MOUSEDIP, IntAct18083102 23334419 details
TRAF3_MOUSETRAF2_MOUSEI2D20818435 details
TRAF3_MOUSETBK1_HUMANDIP, IntAct16306936 27094905 details
TRAF3_MOUSEE2AK2_HUMANDIP16306936 details
TRAF3_MOUSEIRAK1_HUMANDIP16306936 details
TRAF3_MOUSEIKKE_HUMANDIP16306936 details
TRAF3_MOUSEOTU7B_HUMANDIP23334419 details
TRAF3_MOUSETNR5_MOUSEBioGRID, DIP18635759 23334419 25072696 details
TRAF3_MOUSEOTU7B_MOUSEBioGRID, DIP23334419 details
TRAF3_MOUSEMALT1_MOUSEIntAct19917778 details
TRAF3_MOUSETNR19_HUMANBioGRID10809768 details
TRAF3_MOUSETLR4_MOUSEBioGRID19898473 details
TRAF3_MOUSERNF41_MOUSEBioGRID19483718 details
TRAF3_MOUSETR13C_MOUSEBioGRID21041452 details
TRAF3_MOUSECIKS_MOUSEBioGRID22649194 details
TRAF3_MOUSEKSYK_MOUSEBioGRID23962979 details
TRAF3_MOUSENEDD4_MOUSEBioGRID25072696 details
TRAF3_MOUSEASPP1_MOUSEBioGRID25072696 details
TRAF3_MOUSECREB1_MOUSEBioGRID26755589 details
TRAF3_MOUSETRAF6_MOUSEBioGRID26474655 details
TRAF3_MOUSETBK1_MOUSEBioGRID26474655 32324863 details
TRAF3_MOUSECHIP_MOUSEBioGRID25792747 details
TRAF3_MOUSEASC_MOUSEBioGRID25847972 details
TRAF3_MOUSESTK38_MOUSEBioGRID28219902 details
TRAF3_MOUSEI17RA_MOUSEBioGRID28219902 details
TRAF3_MOUSETIF1A_MOUSEBioGRID32324863 details