Entity Details

Primary name DVL2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60838
EntryNameDVL2_MOUSE
FullNameSegment polarity protein dishevelled homolog DVL-2
TaxID10090
Evidenceevidence at protein level
Length736
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesDvl2

GO terms

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GOName
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0005109 frizzled binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006355 regulation of transcription, DNA-templated
GO:0007379 segment specification
GO:0007507 heart development
GO:0016235 aggresome
GO:0016328 lateral plasma membrane
GO:0016604 nuclear body
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0022007 convergent extension involved in neural plate elongation
GO:0030136 clathrin-coated vesicle
GO:0030674 protein-macromolecule adaptor activity
GO:0031267 small GTPase binding
GO:0031410 cytoplasmic vesicle
GO:0034613 cellular protein localization
GO:0035282 segmentation
GO:0035556 intracellular signal transduction
GO:0035567 non-canonical Wnt signaling pathway
GO:0042802 identical protein binding
GO:0043507 positive regulation of JUN kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0043621 protein self-association
GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045177 apical part of cell
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060029 convergent extension involved in organogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0150012 positive regulation of neuron projection arborization

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000591 DEP domainDomainDomain
IPR001158 DIX domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR003351 Dishevelled protein domainDomainDomain
IPR008339 Dishevelled familyFamilyFamily
IPR008341 Dishevelled-2FamilyFamily
IPR015506 Dishevelled-related proteinFamilyFamily
IPR024580 Dishevelled C-terminalDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR038207 DIX domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
DVL2_MOUSEPLCG2_MOUSEIntAct15102471 details
DVL2_MOUSENKD1_MOUSEUniProt11356022 details
DVL2_MOUSENKD2_MOUSEUniProt11356022 details
DVL2_MOUSEVANG1_MOUSEBioGRID, IntAct15456783 details
DVL2_MOUSEVANG2_MOUSEBioGRID, IntAct, UniProt15456783 19701191 details
DVL2_MOUSEDVL2_MOUSEDIP, UniProt17529994 21189423 details
DVL2_MOUSEDIXC1_HUMANUniProt21189423 details
DVL2_MOUSEPLK1_HUMANMINT22609948 details
DVL2_MOUSEKC1E_HUMANMINT22609948 details
DVL2_MOUSEKC1D_HUMANMINT22609948 details
DVL2_MOUSEVANG2_HUMANUniProt20558380 details
DVL2_MOUSEDAAM1_HUMANDIP18162551 details
DVL2_MOUSEVANG1_HUMANIntAct17409324 details
DVL2_MOUSESRC_MOUSEBioGRID19920076 details
DVL2_MOUSEGBRL1_MOUSEBioGRID21691068 details
DVL2_MOUSEAPC_MOUSEMINT20224554 details
DVL2_MOUSEAPC_HUMANMINT20224554 details
DVL2_MOUSEDVL3_MOUSEMolecular Connections21092292 details
DVL2_MOUSEDVL1_MOUSEMolecular Connections21092292 details
DVL2_MOUSEFZD4_HUMANI2D20802536 details
DVL2_MOUSEWWOX_HUMANIntAct25678599 details
DVL2_MOUSEDACT1_MOUSEUniProt19701191 21718540 details
DVL2_MOUSECELR1_HUMANIntAct22632972 details
DVL2_MOUSEDACT1_HUMANUniProt21262972 details
DVL2_MOUSEDAB2_MOUSEUniProt12805222 details
DVL2_MOUSEDACT3_MOUSEUniProt21718540 details
DVL2_MOUSEDACT2_MOUSEUniProt21718540 details
DVL2_MOUSEANKR6_MOUSEDIP17032765 details
DVL2_MOUSEHCK_MOUSEBioGRID19920076 details
DVL2_MOUSEGRB2_MOUSEBioGRID19920076 details
DVL2_MOUSECRK_MOUSEBioGRID19920076 details
DVL2_MOUSEKC1E_MOUSEBioGRID17606995 details
DVL2_MOUSEAXIN1_MOUSEBioGRID15579909 details
DVL2_MOUSESMUF2_MOUSEBioGRID19379695 details
DVL2_MOUSEPAR6A_MOUSEBioGRID19379695 details
DVL2_MOUSESMUF1_MOUSEBioGRID19379695 details
DVL2_MOUSEZBT17_MOUSEBioGRID25558878 details