Entity Details

Primary name RIPK1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60855
EntryNameRIPK1_MOUSE
FullNameReceptor-interacting serine/threonine-protein kinase 1
TaxID10090
Evidenceevidence at protein level
Length656
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesRipk1

GO terms

Show/Hide Table
GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0005123 death receptor binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007257 obsolete activation of JUN kinase activity
GO:0008219 cell death
GO:0010940 positive regulation of necrotic cell death
GO:0010942 positive regulation of cell death
GO:0016032 viral process
GO:0031264 death-inducing signaling complex
GO:0031625 ubiquitin protein ligase binding
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0034612 response to tumor necrosis factor
GO:0036289 peptidyl-serine autophosphorylation
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0044257 cellular protein catabolic process
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060545 positive regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0070105 positive regulation of interleukin-6-mediated signaling pathway
GO:0070231 T cell apoptotic process
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0070513 death domain binding
GO:0070926 regulation of ATP:ADP antiporter activity
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0097342 ripoptosome
GO:0097343 ripoptosome assembly
GO:0097527 necroptotic signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901026 ripoptosome assembly involved in necroptotic process
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905206 positive regulation of hydrogen peroxide-induced cell death
GO:1990000 amyloid fibril formation
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR025735 RHIM domainDomainDomain
IPR037934 RIP1, Death domainDomainDomain

Diseases

Show/Hide Table

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
RIPK1_MOUSETNAP3_MOUSEBioGRID, InnateDB18239685 18246070 21765415 23602765 details
RIPK1_MOUSEHTRA2_HUMANIntAct20125124 details
RIPK1_MOUSEUBB_MOUSEDIP18719121 26649818 details
RIPK1_MOUSEUBC_MOUSEDIP18719121 26649818 details
RIPK1_MOUSERS27A_MOUSEDIP18719121 26649818 details
RIPK1_MOUSERL40_MOUSEDIP18719121 26649818 details
RIPK1_MOUSETNFA_MOUSEBioGRID18621737 19955178 24469399 29203883 29891719 30420664 details
RIPK1_MOUSEKHDR1_MOUSEBioGRID21620750 details
RIPK1_MOUSEBIRC2_HUMANBioGRID18621737 details
RIPK1_MOUSETNR1A_MOUSEBioGRID, DIP, IntAct, MINT16547522 16680093 18022363 18719121 23602765 29203883 29891719 30209212 details
RIPK1_MOUSEM3K8_MOUSEBioGRID, IntAct16291755 details
RIPK1_MOUSEFADD_MOUSEBioGRID, DIP, IntAct18946037 19524513 21052097 21368763 22037414 24144979 24557836 26555174 26649818 27458237 29203883 29891719 30209212 30420664 details
RIPK1_MOUSERIPK3_MOUSEBioGRID, InnateDB, IntAct19524513 22922364 29203883 details
RIPK1_MOUSEITCH_MOUSEBioGRID, InnateDB18246070 21765415 details
RIPK1_MOUSEINAR1_MOUSEInnateDB22922364 details
RIPK1_MOUSECASP8_MOUSEBioGRID, IntAct26555174 29203883 details
RIPK1_MOUSETRADD_MOUSEDIP18719121 details
RIPK1_MOUSETCAM1_MOUSEDIP22454496 details
RIPK1_MOUSETNFA_HUMANDIP26649818 details
RIPK1_MOUSECYLD_MOUSEBioGRID17981138 details
RIPK1_MOUSENEMO_MOUSEBioGRID17981138 22037414 details
RIPK1_MOUSESQSTM_MOUSEBioGRID19850933 details
RIPK1_MOUSETRAF6_MOUSEBioGRID18246070 details
RIPK1_MOUSETAXB1_MOUSEBioGRID18239685 details
RIPK1_MOUSEIL1B_MOUSEBioGRID25607459 details
RIPK1_MOUSETLR3_MOUSEBioGRID25828701 details
RIPK1_MOUSENEK1_MOUSEBioGRID29891719 details
RIPK1_MOUSELRRK2_MOUSEBioGRID29891719 details
RIPK1_MOUSECRADD_MOUSEBioGRID11978827 details
RIPK1_MOUSEMAVS_MOUSEBioGRID31149635 details
RIPK1_MOUSETANK_MOUSEBioGRID31149635 details