Entity Details

Primary name SC6A4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60857
EntryNameSC6A4_MOUSE
FullNameSodium-dependent serotonin transporter
TaxID10090
Evidenceevidence at protein level
Length630
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesSlc6a4

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005335 serotonin:sodium symporter activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006836 neurotransmitter transport
GO:0006837 serotonin transport
GO:0007584 response to nutrient
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0008504 monoamine transmembrane transporter activity
GO:0009636 response to toxic substance
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0012505 endomembrane system
GO:0014064 positive regulation of serotonin secretion
GO:0015844 monoamine transport
GO:0017075 syntaxin-1 binding
GO:0019811 cocaine binding
GO:0021941 negative regulation of cerebellar granule cell precursor proliferation
GO:0032227 negative regulation of synaptic transmission, dopaminergic
GO:0032355 response to estradiol
GO:0035176 social behavior
GO:0035725 sodium ion transmembrane transport
GO:0042310 vasoconstriction
GO:0042493 response to drug
GO:0042713 sperm ejaculation
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045665 negative regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0046621 negative regulation of organ growth
GO:0046872 metal ion binding
GO:0048854 brain morphogenesis
GO:0050998 nitric-oxide synthase binding
GO:0051015 actin filament binding
GO:0051378 serotonin binding
GO:0051610 serotonin uptake
GO:0071300 cellular response to retinoic acid
GO:0071310 cellular response to organic substance
GO:0071321 cellular response to cGMP
GO:0090067 regulation of thalamus size
GO:0098810 neurotransmitter reuptake
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0099154 serotonergic synapse

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Endomembrane system
Endosome membrane

Domains

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DomainNameCategoryType
IPR000175 Sodium:neurotransmitter symporterFamilyFamily
IPR013086 Sodium:neurotransmitter symporter, serotonin, N-terminalDomainDomain
IPR037272 Sodium:neurotransmitter symporter superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions