Entity Details

Primary name ARHG2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ60875
EntryNameARHG2_MOUSE
FullNameRho guanine nucleotide exchange factor 2
TaxID10090
Evidenceevidence at protein level
Length985
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesArhgef2

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0000902 cell morphogenesis
GO:0002102 podosome
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005923 bicellular tight junction
GO:0007015 actin filament organization
GO:0007026 negative regulation of microtubule depolymerization
GO:0008017 microtubule binding
GO:0014069 postsynaptic density
GO:0031267 small GTPase binding
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0032587 ruffle membrane
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0045087 innate immune response
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768 negative regulation of neurogenesis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0055059 asymmetric neuroblast division
GO:0071225 cellular response to muramyl dipeptide
GO:0071802 negative regulation of podosome assembly
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:2001224 positive regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR037806 ARHGEF2, PH domainDomainDomain
IPR041020 ARHGEF1-like, PH domainDomainDomain

Diseases

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