Entity Details

Primary name TSC2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61037
EntryNameTSC2_MOUSE
FullNameTuberin
TaxID10090
Evidenceevidence at protein level
Length1814
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001843 neural tube closure
GO:0001933 negative regulation of protein phosphorylation
GO:0005096 GTPase activator activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005901 caveola
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0007165 signal transduction
GO:0007507 heart development
GO:0007568 aging
GO:0008104 protein localization
GO:0008285 negative regulation of cell population proliferation
GO:0010508 positive regulation of autophagy
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010763 positive regulation of fibroblast migration
GO:0010976 positive regulation of neuron projection development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016239 positive regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0019902 phosphatase binding
GO:0030010 establishment of cell polarity
GO:0030030 cell projection organization
GO:0030100 regulation of endocytosis
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031267 small GTPase binding
GO:0032007 negative regulation of TOR signaling
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033596 TSC1-TSC2 complex
GO:0034394 protein localization to cell surface
GO:0035176 social behavior
GO:0042803 protein homodimerization activity
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle
GO:0043276 anoikis
GO:0043407 negative regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0044861 protein transport into plasma membrane raft
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045184 establishment of protein localization
GO:0045202 synapse
GO:0045785 positive regulation of cell adhesion
GO:0045792 negative regulation of cell size
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046323 glucose import
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0047485 protein N-terminus binding
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048147 negative regulation of fibroblast proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0048550 negative regulation of pinocytosis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050771 negative regulation of axonogenesis
GO:0050918 positive chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051726 regulation of cell cycle
GO:0051879 Hsp90 protein binding
GO:0051898 negative regulation of protein kinase B signaling
GO:0060999 positive regulation of dendritic spine development
GO:0071889 14-3-3 protein binding
GO:0098978 glutamatergic synapse
GO:0099175 regulation of postsynapse organization
GO:1904262 negative regulation of TORC1 signaling
GO:1905563 negative regulation of vascular endothelial cell proliferation

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000331 Rap/Ran-GAP domainDomainDomain
IPR003913 TuberinFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018515 Tuberin-type domainDomainDomain
IPR024584 Tuberin, N-terminalDomainDomain
IPR027107 Tuberin/Ral GTPase-activating protein subunit alphaFamilyFamily
IPR035974 Rap/Ran-GAP superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TSC2_MOUSETSC1_MOUSEIntAct, MINT20412061 28671696 details
TSC2_MOUSE1433G_MOUSEMINT20628654 details