Entity Details

Primary name SIM2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61079
EntryNameSIM2_MOUSE
FullNameSingle-minded homolog 2
TaxID10090
Evidenceevidence at protein level
Length657
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesSim2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0009880 embryonic pattern specification
GO:0016604 nuclear body
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046982 protein heterodimerization activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR001610 PAC motifRepeatRepeat
IPR010578 Single-minded, C-terminalDomainDomain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013655 PAS fold-3DomainDomain
IPR013767 PAS foldDomainDomain
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SIM2_MOUSEARNT_MOUSEIntAct9020169 details
SIM2_MOUSEARNT_HUMANIntAct9704006 details