Entity Details

Primary name KSR1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61097
EntryNameKSR1_MOUSE
FullNameKinase suppressor of Ras 1
TaxID10090
Evidenceevidence at protein level
Length873
SequenceStatuscomplete
DateCreated2004-12-21
DateModified2021-06-02

Ontological Relatives

GenesKsr1

GO terms

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GOName
GO:0000185 obsolete activation of MAPKKK activity
GO:0004672 protein kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0008022 protein C-terminus binding
GO:0016020 membrane
GO:0019901 protein kinase binding
GO:0019933 cAMP-mediated signaling
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0032587 ruffle membrane
GO:0032991 protein-containing complex
GO:0042127 regulation of cell population proliferation
GO:0043405 regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0046872 metal ion binding
GO:0051087 chaperone binding
GO:0051879 Hsp90 protein binding
GO:0071889 14-3-3 protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Endoplasmic reticulum membrane
Membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR025561 Kinase suppressor of RAS, SAM-like domainFamilyFamily

Diseases

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Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
KSR1_MOUSEMP2K2_HUMANBioGRID, MINT10409742 26549023 details
KSR1_MOUSEMP2K1_HUMANBioGRID, MINT10409742 26549023 details
KSR1_MOUSE1433B_HUMANBioGRID, IntAct, MINT10409742 15684389 26549023 details
KSR1_MOUSE1433Z_MOUSEMINT9115393 9858547 details
KSR1_MOUSEMP2K1_MOUSEBioGRID18332145 21144847 details
KSR1_MOUSEKSR1_MOUSEBioGRID21144847 details
KSR1_MOUSEMBP_MOUSEBioGRID21144847 details
KSR1_MOUSEHS90B_HUMANBioGRID, MINT10409742 26549023 details
KSR1_MOUSEHS71A_HUMANMINT10409742 details
KSR1_MOUSEHS71B_HUMANMINT10409742 details
KSR1_MOUSECDC37_HUMANBioGRID, MINT10409742 26549023 details
KSR1_MOUSEMK03_HUMANMINT10409742 details
KSR1_MOUSENDKA_HUMANIntAct15684389 details
KSR1_MOUSE1433G_HUMANBioGRID, MINT18426801 26549023 details
KSR1_MOUSEVRK2_HUMANIntAct22752157 details
KSR1_MOUSEBRAF_HUMANMINT22510884 details
KSR1_MOUSEARHG2_MOUSEIntAct24525234 details
KSR1_MOUSEHS90A_HUMANBioGRID10409742 26549023 details
KSR1_MOUSEHSP74_HUMANBioGRID10409742 26549023 details
KSR1_MOUSEANXA2_HUMANBioGRID10409742 details
KSR1_MOUSEMK01_HUMANBioGRID10409742 26549023 details
KSR1_MOUSERAF1_MOUSEBioGRID18332145 details
KSR1_MOUSEBRAP_MOUSEBioGRID18332145 32325033 details
KSR1_MOUSEMP2K2_MOUSEBioGRID21144847 details
KSR1_MOUSEMARK3_MOUSEBioGRID11741534 details
KSR1_MOUSEMERL_HUMANBioGRID26549023 details
KSR1_MOUSERAF1_HUMANBioGRID26549023 details
KSR1_MOUSEDCAF1_HUMANBioGRID26549023 details
KSR1_MOUSEMK01_MOUSEBioGRID19114553 details
KSR1_MOUSEPA24A_MOUSEBioGRID19114553 details