Entity Details

Primary name PTC1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61115
EntryNamePTC1_MOUSE
FullNameProtein patched homolog 1
TaxID10090
Evidenceevidence at protein level
Length1434
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPtch1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001709 cell fate determination
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0003007 heart morphogenesis
GO:0005113 patched binding
GO:0005119 smoothened binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005929 cilium
GO:0007165 signal transduction
GO:0007224 smoothened signaling pathway
GO:0007346 regulation of mitotic cell cycle
GO:0007389 pattern specification process
GO:0007420 brain development
GO:0008158 hedgehog receptor activity
GO:0008201 heparin binding
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0008544 epidermis development
GO:0009612 response to mechanical stimulus
GO:0009887 animal organ morphogenesis
GO:0009953 dorsal/ventral pattern formation
GO:0009957 epidermal cell fate specification
GO:0010157 response to chlorate
GO:0010875 positive regulation of cholesterol efflux
GO:0014069 postsynaptic density
GO:0015485 cholesterol binding
GO:0016485 protein processing
GO:0021522 spinal cord motor neuron differentiation
GO:0021532 neural tube patterning
GO:0021904 dorsal/ventral neural tube patterning
GO:0021997 neural plate axis specification
GO:0030326 embryonic limb morphogenesis
GO:0030332 cyclin binding
GO:0030496 midbody
GO:0030850 prostate gland development
GO:0030879 mammary gland development
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032880 regulation of protein localization
GO:0035108 limb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0040008 regulation of growth
GO:0040015 negative regulation of multicellular organism growth
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043616 keratinocyte proliferation
GO:0044294 dendritic growth cone
GO:0044295 axonal growth cone
GO:0044877 protein-containing complex binding
GO:0045177 apical part of cell
GO:0045606 positive regulation of epidermal cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048471 perinuclear region of cytoplasm
GO:0048568 embryonic organ development
GO:0048745 smooth muscle tissue development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051782 negative regulation of cell division
GO:0060037 pharyngeal system development
GO:0060603 mammary gland duct morphogenesis
GO:0060644 mammary gland epithelial cell differentiation
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061005 cell differentiation involved in kidney development
GO:0061053 somite development
GO:0071397 cellular response to cholesterol
GO:0071679 commissural neuron axon guidance
GO:0072203 cell proliferation involved in metanephros development
GO:0072205 metanephric collecting duct development
GO:0072659 protein localization to plasma membrane
GO:0097108 hedgehog family protein binding
GO:0097421 liver regeneration

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000731 Sterol-sensing domainDomainDomain
IPR003392 Protein patched/dispatchedFamilyFamily
IPR004766 Transmembrane receptor, patchedFamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PTC1_MOUSEDNJA3_HUMANDIP17230190 details