Entity Details

Primary name PSN2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61144
EntryNamePSN2_MOUSE
FullNamePresenilin-2
TaxID10090
Evidenceevidence at protein level
Length448
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPsen2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0000776 kinetochore
GO:0001708 cell fate specification
GO:0001756 somitogenesis
GO:0001921 positive regulation of receptor recycling
GO:0001933 negative regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002286 T cell activation involved in immune response
GO:0002573 myeloid leukocyte differentiation
GO:0004175 endopeptidase activity
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005743 mitochondrial inner membrane
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0006509 membrane protein ectodomain proteolysis
GO:0006816 calcium ion transport
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0007611 learning or memory
GO:0007613 memory
GO:0008021 synaptic vesicle
GO:0009986 cell surface
GO:0015031 protein transport
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016485 protein processing
GO:0021904 dorsal/ventral neural tube patterning
GO:0030018 Z disc
GO:0030326 embryonic limb morphogenesis
GO:0030426 growth cone
GO:0030900 forebrain development
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031594 neuromuscular junction
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032991 protein-containing complex
GO:0034205 amyloid-beta formation
GO:0035253 ciliary rootlet
GO:0035556 intracellular signal transduction
GO:0036064 ciliary basal body
GO:0040011 locomotion
GO:0042500 aspartic endopeptidase activity, intramembrane cleaving
GO:0042987 amyloid precursor protein catabolic process
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043198 dendritic shaft
GO:0043393 regulation of protein binding
GO:0043589 skin morphogenesis
GO:0044267 cellular protein metabolic process
GO:0045121 membrane raft
GO:0048167 regulation of synaptic plasticity
GO:0048286 lung alveolus development
GO:0048471 perinuclear region of cytoplasm
GO:0048538 thymus development
GO:0048854 brain morphogenesis
GO:0050435 amyloid-beta metabolic process
GO:0050820 positive regulation of coagulation
GO:0050852 T cell receptor signaling pathway
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051604 protein maturation
GO:0060048 cardiac muscle contraction
GO:0070050 neuron cellular homeostasis
GO:0070765 gamma-secretase complex
GO:0097060 synaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0110097 regulation of calcium import into the mitochondrion
GO:0150076 neuroinflammatory response
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR001108 Peptidase A22A, presenilinFamilyFamily
IPR001493 Peptidase A22A, presenilin 2FamilyFamily
IPR006639 Presenilin/signal peptide peptidaseFamilyFamily
IPR042524 Presenilin, C-terminalFamilyHomologous superfamily

Diseases

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