Entity Details

Primary name LAPM5_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61168
EntryNameLAPM5_MOUSE
FullNameLysosomal-associated transmembrane protein 5
TaxID10090
Evidenceevidence at protein level
Length261
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesLaptm5

GO terms

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GOName
GO:0002357 defense response to tumor cell
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005887 integral component of plasma membrane
GO:0006622 protein targeting to lysosome
GO:0006886 intracellular protein transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0012502 induction of programmed cell death
GO:0019899 enzyme binding
GO:0030133 transport vesicle
GO:0031398 positive regulation of protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031625 ubiquitin protein ligase binding
GO:0032689 negative regulation of interferon-gamma production
GO:0032703 negative regulation of interleukin-2 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032991 protein-containing complex
GO:0043410 positive regulation of MAPK cascade
GO:0046007 negative regulation of activated T cell proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050868 negative regulation of T cell activation
GO:0050869 negative regulation of B cell activation
GO:0060907 positive regulation of macrophage cytokine production
GO:0061462 protein localization to lysosome
GO:0090160 Golgi to lysosome transport
GO:0097214 positive regulation of lysosomal membrane permeability
GO:0140036 ubiquitin-dependent protein binding
GO:0140311 protein sequestering activity
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1904093 negative regulation of autophagic cell death
GO:1990830 cellular response to leukemia inhibitory factor
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000646 positive regulation of receptor catabolic process

Subcellular Location

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Subcellular Location
Lysosome membrane

Domains

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DomainNameCategoryType
IPR004687 Lysosomal-associated transmembrane protein 4/5FamilyFamily
IPR018396 Lysosomal-associated transmembrane protein, 4A/5FamilyFamily
IPR018397 Lysosomal-associated transmembrane protein 5FamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
LAPM5_MOUSENEDD4_MOUSEBioGRID, DIP18562292 details
LAPM5_MOUSECD3Z_MOUSEMINT20150895 details