Entity Details

Primary name EZH2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61188
EntryNameEZH2_MOUSE
FullNameHistone-lysine N-methyltransferase EZH2
TaxID10090
Evidenceevidence at protein level
Length746
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesEzh2

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001932 regulation of protein phosphorylation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005677 chromatin silencing complex
GO:0005737 cytoplasm
GO:0006306 DNA methylation
GO:0006348 chromatin silencing at telomere
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008284 positive regulation of cell population proliferation
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014013 regulation of gliogenesis
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016279 protein-lysine N-methyltransferase activity
GO:0016571 histone methylation
GO:0018024 histone-lysine N-methyltransferase activity
GO:0021695 cerebellar cortex development
GO:0021766 hippocampus development
GO:0030183 B cell differentiation
GO:0031490 chromatin DNA binding
GO:0032355 response to estradiol
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035098 ESC/E(Z) complex
GO:0035984 cellular response to trichostatin A
GO:0036333 hepatocyte homeostasis
GO:0042054 histone methyltransferase activity
GO:0042127 regulation of cell population proliferation
GO:0042752 regulation of circadian rhythm
GO:0043021 ribonucleoprotein complex binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043547 positive regulation of GTPase activity
GO:0043565 sequence-specific DNA binding
GO:0045120 pronucleus
GO:0045605 negative regulation of epidermal cell differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046976 histone methyltransferase activity (H3-K27 specific)
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0048468 cell development
GO:0048511 rhythmic process
GO:0050767 regulation of neurogenesis
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0070301 cellular response to hydrogen peroxide
GO:0070314 G1 to G0 transition
GO:0070734 histone H3-K27 methylation
GO:0070878 primary miRNA binding
GO:0071168 protein localization to chromatin
GO:0071707 immunoglobulin heavy chain V-D-J recombination
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0097421 liver regeneration
GO:0098532 histone H3-K27 trimethylation
GO:1900006 positive regulation of dendrite development
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:1904772 response to tetrachloromethane
GO:1990841 promoter-specific chromatin binding
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

Show/Hide Table
Subcellular Location
Chromosome
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001005 SANT/Myb domainDomainDomain
IPR001214 SET domainDomainDomain
IPR021654 Histone-lysine N-methyltransferase EZH1/EZH2FamilyFamily
IPR026489 CXC domainDomainDomain
IPR033467 Tesmin/TSO1-like CXC domainDomainDomain
IPR041343 Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domainDomainDomain
IPR041355 Pre-SET CXC domainDomainDomain
IPR044439 EZH2, SET domainDomainDomain

Diseases

Show/Hide Table

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
EZH2_MOUSEEED_MOUSEBioGRID, DIP, IntAct, MINT12900441 17937919 20064375 20064376 20075857 22094255 22438827 23624935 24457600 25680957 9742080 details
EZH2_MOUSEBRCA1_HUMANMINT23624935 details
EZH2_MOUSEDNM3L_MOUSEIntAct24074865 details
EZH2_MOUSECITE4_MOUSEBioGRID, IntAct20211142 details
EZH2_MOUSEH31T_HUMANBioGRID22619169 details
EZH2_MOUSEMYOD1_MOUSEBioGRID22333916 details
EZH2_MOUSEH33_MOUSEBioGRID23948251 details
EZH2_MOUSEATRX_MOUSEBioGRID25417162 details
EZH2_MOUSESUZ12_MOUSEBioGRID, DIP, IntAct, MINT20064375 20064376 20075857 20123894 22438827 23624935 24040135 24074865 25680957 details
EZH2_MOUSEJARD2_MOUSEBioGRID, DIP, IntAct, MINT20064375 20064376 20075857 20123894 21811233 25680957 details
EZH2_MOUSEMTF2_MOUSEBioGRID, IntAct20064376 20123894 25680957 details
EZH2_MOUSERBBP4_MOUSEBioGRID, IntAct20064376 20123894 25680957 details
EZH2_MOUSEAEBP2_MOUSEBioGRID, IntAct20064376 20123894 25680957 details
EZH2_MOUSEPHF1_MOUSEBioGRID20123894 32325033 details
EZH2_MOUSECLOCK_MOUSEBioGRID16717091 details
EZH2_MOUSEBMAL1_MOUSEBioGRID16717091 details
EZH2_MOUSECRY1_MOUSEBioGRID16717091 details
EZH2_MOUSERBL2_MOUSEBioGRID15077161 details
EZH2_MOUSEPHF19_MOUSEBioGRID22438827 23104054 details
EZH2_MOUSEH1FNT_MOUSEBioGRID22323620 details
EZH2_MOUSERPB1_MOUSEBioGRID22305566 details
EZH2_MOUSECUL3_MOUSEBioGRID23086144 details
EZH2_MOUSESSXT_MOUSEBioGRID22439931 details
EZH2_MOUSEASXL2_MOUSEBioGRID24040135 details
EZH2_MOUSEMDM2_MOUSEBioGRID26748827 details
EZH2_MOUSEPJA1_MOUSEBioGRID28067271 details
EZH2_MOUSEASCL1_MOUSEBioGRID20506217 details
EZH2_MOUSEEZHIP_MOUSEBioGRID31281901 details