Entity Details

Primary name HIF1A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61221
EntryNameHIF1A_MOUSE
FullNameHypoxia-inducible factor 1-alpha
TaxID10090
Evidenceevidence at protein level
Length836
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesHif1a

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000302 response to reactive oxygen species
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001666 response to hypoxia
GO:0001755 neural crest cell migration
GO:0001837 epithelial to mesenchymal transition
GO:0001892 embryonic placenta development
GO:0001922 B-1 B cell homeostasis
GO:0001944 vasculature development
GO:0001947 heart looping
GO:0002039 p53 binding
GO:0002052 positive regulation of neuroblast proliferation
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0003151 outflow tract morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006089 lactate metabolic process
GO:0006110 regulation of glycolytic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006879 cellular iron ion homeostasis
GO:0007165 signal transduction
GO:0007595 lactation
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008542 visual learning
GO:0010039 response to iron ion
GO:0010468 regulation of gene expression
GO:0010508 positive regulation of autophagy
GO:0010573 vascular endothelial growth factor production
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0014850 response to muscle activity
GO:0016239 positive regulation of macroautophagy
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0019896 axonal transport of mitochondrion
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021502 neural fold elevation formation
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030502 negative regulation of bone mineralization
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031514 motile cilium
GO:0031625 ubiquitin protein ligase binding
GO:0032007 negative regulation of TOR signaling
GO:0032364 oxygen homeostasis
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032963 collagen metabolic process
GO:0032991 protein-containing complex
GO:0035035 histone acetyltransferase binding
GO:0035162 embryonic hemopoiesis
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127 regulation of cell population proliferation
GO:0042541 hemoglobin biosynthetic process
GO:0042593 glucose homeostasis
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043565 sequence-specific DNA binding
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0044877 protein-containing complex binding
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045906 negative regulation of vasoconstriction
GO:0045926 negative regulation of growth
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046716 muscle cell cellular homeostasis
GO:0046886 positive regulation of hormone biosynthetic process
GO:0046982 protein heterodimerization activity
GO:0048514 blood vessel morphogenesis
GO:0048546 digestive tract morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050790 regulation of catalytic activity
GO:0051216 cartilage development
GO:0051541 elastin metabolic process
GO:0051879 Hsp90 protein binding
GO:0060574 intestinal epithelial cell maturation
GO:0060992 response to fungicide
GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development
GO:0061072 iris morphogenesis
GO:0061298 retina vasculature development in camera-type eye
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070101 positive regulation of chemokine-mediated signaling pathway
GO:0070243 regulation of thymocyte apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070888 E-box binding
GO:0071347 cellular response to interleukin-1
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:0090575 RNA polymerase II transcription regulator complex
GO:0097411 hypoxia-inducible factor-1alpha signaling pathway
GO:0098586 cellular response to virus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903599 positive regulation of autophagy of mitochondrion
GO:1903715 regulation of aerobic respiration
GO:1904115 axon cytoplasm
GO:2000273 positive regulation of signaling receptor activity
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000434 regulation of protein neddylation
GO:2001054 negative regulation of mesenchymal cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR001321 Hypoxia-inducible factor-1 alphaFamilyFamily
IPR001610 PAC motifRepeatRepeat
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013655 PAS fold-3DomainDomain
IPR013767 PAS foldDomainDomain
IPR014887 HIF-1 alpha, transactivation domain, C-terminalDomainDomain
IPR021537 Hypoxia-inducible factor, alpha subunitFamilyFamily
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
HIF1A_MOUSENECD_MOUSEBioGRID, MINT15978586 17826745 details
HIF1A_MOUSEARNT_MOUSEBioGRID, DIP, IntAct10873592 20609350 26245371 8816435 details
HIF1A_MOUSETSG10_MOUSEMINT16777103 details
HIF1A_MOUSEVHL_HUMANIntAct11292862 details
HIF1A_MOUSETLX3_MOUSEBioGRID, IntAct20211142 details
HIF1A_MOUSEBMAL1_MOUSEBioGRID20211142 9704006 details
HIF1A_MOUSEVHL_MOUSEBioGRID11859074 12468553 17981124 20211142 29279301 details
HIF1A_MOUSECSN5_HUMANBioGRID11707426 details
HIF1A_MOUSEP53_HUMANBioGRID11707426 details
HIF1A_MOUSEUBC9_MOUSEBioGRID17981124 details
HIF1A_MOUSESENP1_MOUSEBioGRID17981124 details
HIF1A_MOUSESNAI1_MOUSEBioGRID21257819 details
HIF1A_MOUSESUMO1_MOUSEMINT15225651 details
HIF1A_MOUSEHDAC4_HUMANMINT19071119 details
HIF1A_MOUSEHDAC5_HUMANMINT19071119 details
HIF1A_MOUSEFOXA2_MOUSEIntAct20609350 details
HIF1A_MOUSEEP300_HUMANIntAct20609350 details
HIF1A_MOUSERORG_MOUSEIntAct21871655 details
HIF1A_MOUSERFOX3_MOUSEIntAct21871655 details
HIF1A_MOUSEE2F8_MOUSEMINT22903062 details
HIF1A_MOUSEMYC_MOUSEIntAct24360282 details
HIF1A_MOUSESMAD3_MOUSEBioGRID17053163 details
HIF1A_MOUSEEP300_MOUSEBioGRID18268343 details
HIF1A_MOUSEFOXO3_MOUSEBioGRID18268343 details
HIF1A_MOUSEATF4_MOUSEBioGRID23649506 details
HIF1A_MOUSEEGLN2_MOUSEBioGRID23649506 details
HIF1A_MOUSEEGLN1_MOUSEBioGRID23649506 details
HIF1A_MOUSEEGLN3_MOUSEBioGRID23649506 details
HIF1A_MOUSEHS71B_MOUSEBioGRID28116619 details
HIF1A_MOUSEHS90A_MOUSEBioGRID28116619 details
HIF1A_MOUSEMTF1_MOUSEBioGRID18337454 details
HIF1A_MOUSEHIF3A_MOUSEBioGRID21546903 details
HIF1A_MOUSEVEGFA_MOUSEBioGRID21257819 details
HIF1A_MOUSEHDAC7_MOUSEBioGRID23853092 details