Entity Details

Primary name APC_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61315
EntryNameAPC_MOUSE
FullNameAdenomatous polyposis coli protein
TaxID10090
Evidenceevidence at protein level
Length2845
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000281 mitotic cytokinesis
GO:0000776 kinetochore
GO:0001708 cell fate specification
GO:0001822 kidney development
GO:0001942 hair follicle development
GO:0002020 protease binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005923 bicellular tight junction
GO:0005938 cell cortex
GO:0006974 cellular response to DNA damage stimulus
GO:0007026 negative regulation of microtubule depolymerization
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007163 establishment or maintenance of cell polarity
GO:0007389 pattern specification process
GO:0007399 nervous system development
GO:0007409 axonogenesis
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
GO:0008285 negative regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009798 axis specification
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0010942 positive regulation of cell death
GO:0015630 microtubule cytoskeleton
GO:0016055 Wnt signaling pathway
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0016477 cell migration
GO:0019827 stem cell population maintenance
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030672 synaptic vesicle membrane
GO:0030856 regulation of epithelial cell differentiation
GO:0030877 beta-catenin destruction complex
GO:0031116 positive regulation of microtubule polymerization
GO:0031122 cytoplasmic microtubule organization
GO:0031175 neuron projection development
GO:0031253 cell projection membrane
GO:0031274 positive regulation of pseudopodium assembly
GO:0031625 ubiquitin protein ligase binding
GO:0031965 nuclear membrane
GO:0032587 ruffle membrane
GO:0032886 regulation of microtubule-based process
GO:0032991 protein-containing complex
GO:0033077 T cell differentiation in thymus
GO:0034750 Scrib-APC-beta-catenin complex
GO:0035019 somatic stem cell population maintenance
GO:0042483 negative regulation of odontogenesis
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043409 negative regulation of MAPK cascade
GO:0043588 skin development
GO:0044295 axonal growth cone
GO:0044306 neuron projection terminus
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045295 gamma-catenin binding
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785 positive regulation of cell adhesion
GO:0046716 muscle cell cellular homeostasis
GO:0048471 perinuclear region of cytoplasm
GO:0048538 thymus development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051010 microtubule plus-end binding
GO:0051171 regulation of nitrogen compound metabolic process
GO:0051276 chromosome organization
GO:0051726 regulation of cell cycle
GO:0051781 positive regulation of cell division
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0060041 retina development in camera-type eye
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060070 canonical Wnt signaling pathway
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0065003 protein-containing complex assembly
GO:0070840 dynein complex binding
GO:0070852 cell body fiber
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1904781 positive regulation of protein localization to centrosome
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000211 regulation of glutamate metabolic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000225 ArmadilloRepeatRepeat
IPR009223 Adenomatous polyposis coli protein repeatRepeatRepeat
IPR009224 SAMPRepeatRepeat
IPR009232 EB-1 bindingDomainDomain
IPR009234 Adenomatous polyposis coli protein basic domainDomainDomain
IPR009240 Adenomatous polyposis coli protein, 15 residue repeatRepeatRepeat
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR026818 Adenomatous polyposis coli (APC) familyFamilyFamily
IPR026831 Adenomatous polyposis coli proteinFamilyHomologous superfamily
IPR026836 Adenomatous polyposis coliFamilyFamily
IPR032038 Adenomatous polyposis coli, N-terminal dimerisation domainDomainDomain
IPR036149 APC, N-terminal coiled-coil domain superfamilyFamilyHomologous superfamily
IPR041257 Adenomatous polyposis coli (APC) repeatRepeatRepeat

Diseases

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Interactions

3 interactions