Entity Details

Primary name NEP_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61391
EntryNameNEP_MOUSE
FullNameNeprilysin
TaxID10090
Evidenceevidence at protein level
Length750
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMme

GO terms

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GOName
GO:0001786 phosphatidylserine binding
GO:0001822 kidney development
GO:0001890 placenta development
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0007611 learning or memory
GO:0008021 synaptic vesicle
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008238 exopeptidase activity
GO:0008270 zinc ion binding
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0019233 sensory perception of pain
GO:0030324 lung development
GO:0030424 axon
GO:0030425 dendrite
GO:0031410 cytoplasmic vesicle
GO:0042277 peptide binding
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0044306 neuron projection terminus
GO:0045121 membrane raft
GO:0045202 synapse
GO:0046449 creatinine metabolic process
GO:0050435 amyloid-beta metabolic process
GO:0050769 positive regulation of neurogenesis
GO:0061837 neuropeptide processing
GO:0070012 oligopeptidase activity
GO:0071345 cellular response to cytokine stimulus
GO:0071492 cellular response to UV-A
GO:0071493 cellular response to UV-B
GO:0090399 replicative senescence
GO:0097242 amyloid-beta clearance
GO:0098793 presynapse
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901612 cardiolipin binding

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000718 Peptidase M13FamilyFamily
IPR008753 Peptidase M13, N-terminal domainDomainDomain
IPR018497 Peptidase M13, C-terminal domainDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR029727 NeprilysinFamilyFamily
IPR042089 Peptidase M13, domain 2FamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
NEP_MOUSEACTB_MOUSEBioGRID15944124 details
NEP_MOUSEADA10_MOUSEBioGRID15944124 details