Entity Details

Primary name ERBB3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61526
EntryNameERBB3_MOUSE
FullNameReceptor tyrosine-protein kinase erbB-3
TaxID10090
Evidenceevidence at protein level
Length1339
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesErbb3

GO terms

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GOName
GO:0003197 endocardial cushion development
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005887 integral component of plasma membrane
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007422 peripheral nervous system development
GO:0008284 positive regulation of cell population proliferation
GO:0009925 basal plasma membrane
GO:0009968 negative regulation of signal transduction
GO:0010628 positive regulation of gene expression
GO:0014037 Schwann cell differentiation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0019838 growth factor binding
GO:0021545 cranial nerve development
GO:0030296 protein tyrosine kinase activator activity
GO:0031625 ubiquitin protein ligase binding
GO:0033674 positive regulation of kinase activity
GO:0038131 neuregulin receptor activity
GO:0038132 neuregulin binding
GO:0038143 ERBB3:ERBB2 complex
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0043235 receptor complex
GO:0043524 negative regulation of neuron apoptotic process
GO:0045211 postsynaptic membrane
GO:0046326 positive regulation of glucose import
GO:0046982 protein heterodimerization activity
GO:0051048 negative regulation of secretion
GO:0051402 neuron apoptotic process
GO:0055025 positive regulation of cardiac muscle tissue development
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptorFamilyFamily
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR032778 Growth factor receptor domain 4DomainDomain
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ERBB3_MOUSEPA2G4_HUMANUniProt11325528 details
ERBB3_MOUSEERBB2_MOUSEI2D20639901 details