Entity Details

Primary name ERBB4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61527
EntryNameERBB4_MOUSE
FullNameReceptor tyrosine-protein kinase erbB-4
TaxID10090
Evidenceevidence at protein level
Length1308
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesErbb4

GO terms

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GOName
GO:0000976 transcription cis-regulatory region binding
GO:0001755 neural crest cell migration
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0007507 heart development
GO:0007595 lactation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009880 embryonic pattern specification
GO:0009925 basal plasma membrane
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0016323 basolateral plasma membrane
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021551 central nervous system morphogenesis
GO:0021889 olfactory bulb interneuron differentiation
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0033674 positive regulation of kinase activity
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038132 neuregulin binding
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043129 surfactant homeostasis
GO:0043235 receptor complex
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045121 membrane raft
GO:0045165 cell fate commitment
GO:0045211 postsynaptic membrane
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046326 positive regulation of glucose import
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046777 protein autophosphorylation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060074 synapse maturation
GO:0060644 mammary gland epithelial cell differentiation
GO:0060749 mammary gland alveolus development
GO:0061026 cardiac muscle tissue regeneration
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099061 integral component of postsynaptic density membrane
GO:2000010 positive regulation of protein localization to cell surface
GO:2001223 negative regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell membrane
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR032778 Growth factor receptor domain 4DomainDomain
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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