Entity Details

Primary name AP180_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61548
EntryNameAP180_MOUSE
FullNameClathrin coat assembly protein AP180
TaxID10090
Evidenceevidence at protein level
Length901
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesSnap91

GO terms

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GOName
GO:0000149 SNARE binding
GO:0000822 inositol hexakisphosphate binding
GO:0005545 1-phosphatidylinositol binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006900 vesicle budding from membrane
GO:0007163 establishment or maintenance of cell polarity
GO:0007268 chemical synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007409 axonogenesis
GO:0008021 synaptic vesicle
GO:0014069 postsynaptic density
GO:0015031 protein transport
GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane
GO:0019901 protein kinase binding
GO:0030100 regulation of endocytosis
GO:0030122 AP-2 adaptor complex
GO:0030136 clathrin-coated vesicle
GO:0031313 extrinsic component of endosome membrane
GO:0032050 clathrin heavy chain binding
GO:0035615 clathrin adaptor activity
GO:0042169 SH2 domain binding
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043274 phospholipase binding
GO:0043679 axon terminus
GO:0045211 postsynaptic membrane
GO:0048268 clathrin coat assembly
GO:0048488 synaptic vesicle endocytosis
GO:0048666 neuron development
GO:0048787 presynaptic active zone membrane
GO:0050772 positive regulation of axonogenesis
GO:0051223 regulation of protein transport
GO:0072583 clathrin-dependent endocytosis
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098688 parallel fiber to Purkinje cell synapse
GO:0098830 presynaptic endosome
GO:0098833 presynaptic endocytic zone
GO:0098894 extrinsic component of presynaptic endocytic zone membrane
GO:1900242 regulation of synaptic vesicle endocytosis
GO:1900244 positive regulation of synaptic vesicle endocytosis
GO:1900275 negative regulation of phospholipase C activity
GO:1904006 negative regulation of phospholipase D activity
GO:1905445 positive regulation of clathrin coat assembly
GO:2000331 regulation of terminal button organization
GO:2000369 regulation of clathrin-dependent endocytosis
GO:2000809 positive regulation of synaptic vesicle clustering

Subcellular Location

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Subcellular Location
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR008942 ENTH/VHSFamilyHomologous superfamily
IPR011417 AP180 N-terminal homology (ANTH) domainDomainDomain
IPR013809 ENTH domainDomainDomain
IPR014712 ANTH domain superfamilyFamilyHomologous superfamily
IPR030428 Clathrin coat assembly protein AP180FamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
AP180_MOUSEAP2A2_MOUSEBioGRID, MINT32325033 7730311 details