Entity Details

Primary name FBN1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61554
EntryNameFBN1_MOUSE
FullNameFibrillin-1
TaxID10090
Evidenceevidence at protein level
Length2873
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesFbn1

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001527 microfibril
GO:0001656 metanephros development
GO:0001822 kidney development
GO:0005178 integrin binding
GO:0005179 hormone activity
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0006006 glucose metabolic process
GO:0007507 heart development
GO:0008201 heparin binding
GO:0009653 anatomical structure morphogenesis
GO:0010737 protein kinase A signaling
GO:0031012 extracellular matrix
GO:0033627 cell adhesion mediated by integrin
GO:0034199 activation of protein kinase A activity
GO:0035582 sequestering of BMP in extracellular matrix
GO:0035583 sequestering of TGFbeta in extracellular matrix
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043010 camera-type eye development
GO:0044877 protein-containing complex binding
GO:0045671 negative regulation of osteoclast differentiation
GO:0048048 embryonic eye morphogenesis
GO:0048050 post-embryonic eye morphogenesis
GO:0062023 collagen-containing extracellular matrix
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:2001205 negative regulation of osteoclast development

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011398 FibrillinFamilyFamily
IPR017878 TB domainDomainDomain
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR026823 Complement Clr-like EGF domainDomainDomain
IPR036773 TGF-beta binding (TB) domain superfamilyFamilyHomologous superfamily
IPR040872 Fibrillin 1, unique N-terminal domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
FBN1_MOUSEDUX4_HUMANBioGRID, IntAct26816005 details