Entity Details

Primary name FGFR3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61851
EntryNameFGFR3_MOUSE
FullNameFibroblast growth factor receptor 3
TaxID10090
Evidenceevidence at protein level
Length801
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002009 morphogenesis of an epithelium
GO:0002089 lens morphogenesis in camera-type eye
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009898 cytoplasmic side of plasma membrane
GO:0009986 cell surface
GO:0010518 positive regulation of phospholipase activity
GO:0010629 negative regulation of gene expression
GO:0010712 regulation of collagen metabolic process
GO:0014003 oligodendrocyte development
GO:0017134 fibroblast growth factor binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021762 substantia nigra development
GO:0022010 central nervous system myelination
GO:0030133 transport vesicle
GO:0030154 cell differentiation
GO:0030278 regulation of ossification
GO:0030282 bone mineralization
GO:0030501 positive regulation of bone mineralization
GO:0030900 forebrain development
GO:0031398 positive regulation of protein ubiquitination
GO:0033674 positive regulation of kinase activity
GO:0035019 somatic stem cell population maintenance
GO:0036342 post-anal tail morphogenesis
GO:0038066 p38MAPK cascade
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043525 positive regulation of neuron apoptotic process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045596 negative regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045839 negative regulation of mitotic nuclear division
GO:0045879 negative regulation of smoothened signaling pathway
GO:0046777 protein autophosphorylation
GO:0046850 regulation of bone remodeling
GO:0048471 perinuclear region of cytoplasm
GO:0048546 digestive tract morphogenesis
GO:0048640 negative regulation of developmental growth
GO:0048678 response to axon injury
GO:0048712 negative regulation of astrocyte differentiation
GO:0048839 inner ear development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051216 cartilage development
GO:0060113 inner ear receptor cell differentiation
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060385 axonogenesis involved in innervation
GO:0061144 alveolar secondary septum development
GO:0061430 bone trabecula morphogenesis
GO:0070307 lens fiber cell development
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070977 bone maturation
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0072148 epithelial cell fate commitment
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0090102 cochlea development
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902178 fibroblast growth factor receptor apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016248 Fibroblast growth factor receptor familyFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041159 Fibroblast growth factor receptor, transmembrane domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
FGFR3_MOUSESH2B2_MOUSEMINT11827956 details
FGFR3_MOUSEKLOT_MOUSEDIP19966287 details