Entity Details

Primary name NPM_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ61937
EntryNameNPM_MOUSE
FullNameNucleophosmin
TaxID10090
Evidenceevidence at protein level
Length292
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesNpm1

GO terms

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GOName
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001046 core promoter sequence-specific DNA binding
GO:0001558 regulation of cell growth
GO:0001652 granular component
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0004860 protein kinase inhibitor activity
GO:0005524 ATP binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0006407 rRNA export from nucleus
GO:0006884 cell volume homeostasis
GO:0006913 nucleocytoplasmic transport
GO:0007098 centrosome cycle
GO:0007569 cell aging
GO:0008104 protein localization
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009303 rRNA transcription
GO:0010608 posttranscriptional regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010824 regulation of centrosome duplication
GO:0010825 positive regulation of centrosome duplication
GO:0010826 negative regulation of centrosome duplication
GO:0015934 large ribosomal subunit
GO:0015935 small ribosomal subunit
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0019843 rRNA binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030957 Tat protein binding
GO:0031328 positive regulation of cellular biosynthetic process
GO:0031398 positive regulation of protein ubiquitination
GO:0031616 spindle pole centrosome
GO:0031647 regulation of protein stability
GO:0032071 regulation of endodeoxyribonuclease activity
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0034644 cellular response to UV
GO:0042273 ribosomal large subunit biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043023 ribosomal large subunit binding
GO:0043024 ribosomal small subunit binding
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043422 protein kinase B binding
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045727 positive regulation of translation
GO:0045740 positive regulation of DNA replication
GO:0045860 positive regulation of protein kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046599 regulation of centriole replication
GO:0047485 protein N-terminus binding
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050821 protein stabilization
GO:0051054 positive regulation of DNA metabolic process
GO:0051059 NF-kappaB binding
GO:0051082 unfolded protein binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051726 regulation of cell cycle
GO:0060699 regulation of endoribonuclease activity
GO:0060735 regulation of eIF2 alpha phosphorylation by dsRNA
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
GO:1902629 regulation of mRNA stability involved in cellular response to UV
GO:1902751 positive regulation of cell cycle G2/M phase transition
GO:1904751 positive regulation of protein localization to nucleolus
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004301 Nucleoplasmin familyFamilyFamily
IPR024057 Nucleoplasmin core domainDomainDomain
IPR032569 Nucleophosmin, C-terminalDomainDomain
IPR036824 Nucleoplasmin core domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
NPM_MOUSENPM3_MOUSEMINT15596447 details
NPM_MOUSERS15_MOUSEMINT15596447 details
NPM_MOUSEYBOX1_MOUSEMINT15596447 details
NPM_MOUSERS27_MOUSEMINT15596447 details
NPM_MOUSEGPAN1_MOUSEMINT15596447 details
NPM_MOUSEFBXW7_MOUSEBioGRID18625840 details
NPM_MOUSECDK2_MOUSEBioGRID16376875 details
NPM_MOUSEMDM2_HUMANUniProt15144954 details
NPM_MOUSERSLBA_MOUSEMINT20168301 details
NPM_MOUSENUCL_MOUSEBioGRID, IntAct18809582 21048921 32325033 details
NPM_MOUSEP53_MOUSEBioGRID17277230 details
NPM_MOUSESRSF2_MOUSEBioGRID16376875 details
NPM_MOUSERL7_MOUSEBioGRID18809582 details
NPM_MOUSERS3_MOUSEBioGRID18809582 details
NPM_MOUSERL4_MOUSEBioGRID18809582 details
NPM_MOUSERL5_MOUSEBioGRID16648475 18809582 32325033 details
NPM_MOUSERL13A_MOUSEBioGRID18809582 details
NPM_MOUSERL22_MOUSEBioGRID18809582 32325033 details
NPM_MOUSERL27_MOUSEBioGRID18809582 details
NPM_MOUSERS3A_MOUSEBioGRID18809582 details
NPM_MOUSERS5_MOUSEBioGRID18809582 details
NPM_MOUSERS6_MOUSEBioGRID18809582 details
NPM_MOUSERS7_MOUSEBioGRID18809582 details
NPM_MOUSECPSF6_MOUSEBioGRID18809582 details
NPM_MOUSEROA1_MOUSEBioGRID18809582 details
NPM_MOUSEHNRH2_MOUSEBioGRID18809582 details
NPM_MOUSEEF2_MOUSEBioGRID18809582 details
NPM_MOUSEDDX1_MOUSEBioGRID18809582 details
NPM_MOUSEDHX9_MOUSEBioGRID18809582 details
NPM_MOUSEEBPL_MOUSEBioGRID18809582 details
NPM_MOUSENUP50_MOUSEBioGRID18809582 details
NPM_MOUSENUP62_MOUSEBioGRID18809582 details
NPM_MOUSEBRCA1_MOUSEBioGRID18809582 details
NPM_MOUSEPARP1_HUMANBioGRID15615785 details
NPM_MOUSEPARP2_HUMANBioGRID15615785 details
NPM_MOUSEPARP2_MOUSEBioGRID15615785 details
NPM_MOUSEROCK2_MOUSEBioGRID17015463 details
NPM_MOUSEVIME_MOUSEBioGRID17015463 details
NPM_MOUSECDN2A_MOUSEBioGRID15485902 details
NPM_MOUSEARF_MOUSEBioGRID15485902 details
NPM_MOUSEE2AK2_MOUSEBioGRID12882984 details