Entity Details

Primary name M3K7_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ62073
EntryNameM3K7_MOUSE
FullNameMitogen-activated protein kinase kinase kinase 7
TaxID10090
Evidenceevidence at protein level
Length579
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesMap3k7

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000287 magnesium ion binding
GO:0001525 angiogenesis
GO:0001649 osteoblast differentiation
GO:0001841 neural tube formation
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007252 I-kappaB phosphorylation
GO:0007254 JNK cascade
GO:0008349 MAP kinase kinase kinase kinase activity
GO:0014069 postsynaptic density
GO:0016239 positive regulation of macroautophagy
GO:0018107 peptidyl-threonine phosphorylation
GO:0030971 receptor tyrosine kinase binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043276 anoikis
GO:0043507 positive regulation of JUN kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0060348 bone development
GO:0060546 negative regulation of necroptotic process
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017421 Mitogen-activated protein (MAP) kinase kinase kinase 7FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
M3K7_MOUSETAB2_HUMANBioGRID, DIP, IntAct10882101 17158449 19675569 details
M3K7_MOUSESMAD1_MOUSEMINT19536134 details
M3K7_MOUSEIKKB_HUMANHPIDb16301747 details
M3K7_MOUSETAB1_HUMANBioGRID, DIP19675569 details
M3K7_MOUSESKIL_MOUSEBioGRID17276978 details
M3K7_MOUSEUBC_MOUSEBioGRID28190767 29676259 details
M3K7_MOUSEVRK2_HUMANIntAct17709393 details
M3K7_MOUSEJIP1_MOUSEBioGRID, IntAct17709393 details
M3K7_MOUSETAB2_MOUSEBioGRID, IntAct, MINT17158449 17384642 19026643 19843958 19955178 24270572 31127032 details
M3K7_MOUSETAB3_HUMANIntAct17158449 details
M3K7_MOUSETAB1_MOUSEBioGRID, IntAct, MINT15218018 19026643 20813258 29143862 details
M3K7_MOUSESMAD9_MOUSEMINT19536134 details
M3K7_MOUSESMAD5_MOUSEMINT19536134 details
M3K7_MOUSETRAF6_HUMANBioGRID, InnateDB10882101 21822258 details
M3K7_MOUSETRAF2_MOUSEBioGRID, InnateDB22057290 details
M3K7_MOUSETRAF6_MOUSEBioGRID, InnateDB18635759 19898473 22057290 22637723 22649194 23960234 24558484 25828701 26474655 details
M3K7_MOUSEDAB2_MOUSEUniProt15894542 details
M3K7_MOUSECAR11_MOUSEBioGRID, HPIDb16301747 details
M3K7_MOUSETNFA_HUMANDIP26649818 details
M3K7_MOUSEMALT1_MOUSEBioGRID16831874 details
M3K7_MOUSEBCL10_MOUSEBioGRID16831874 22411628 details
M3K7_MOUSEIRAK1_MOUSEBioGRID16831874 details
M3K7_MOUSEPELI2_MOUSEBioGRID16831874 details
M3K7_MOUSENEMO_MOUSEBioGRID19898473 21566132 details
M3K7_MOUSEMIB2_MOUSEBioGRID21896478 details
M3K7_MOUSETAB3_MOUSEBioGRID17384642 19955178 31127032 details
M3K7_MOUSETM115_MOUSEBioGRID19955178 details
M3K7_MOUSETLR4_MOUSEBioGRID19898473 details
M3K7_MOUSEBIRC2_MOUSEBioGRID19898473 details
M3K7_MOUSEBIRC3_MOUSEBioGRID19898473 details
M3K7_MOUSEMYD88_MOUSEBioGRID19898473 details
M3K7_MOUSEUBE2N_MOUSEBioGRID19898473 details
M3K7_MOUSEMP2K4_MOUSEBioGRID19898473 details
M3K7_MOUSETNR5_MOUSEBioGRID18635759 details
M3K7_MOUSEM3K7_MOUSEBioGRID17384642 18635759 details
M3K7_MOUSEMP2K6_MOUSEBioGRID21606198 details
M3K7_MOUSEVRK2_MOUSEBioGRID17709393 details
M3K7_MOUSECIKS_MOUSEBioGRID22649194 details
M3K7_MOUSESASH1_MOUSEBioGRID23776175 details
M3K7_MOUSEKSYK_MOUSEBioGRID23962979 details
M3K7_MOUSETBE_MOUSEBioGRID23973329 details
M3K7_MOUSETLR3_MOUSEBioGRID25828701 details
M3K7_MOUSEGSK3B_MOUSEBioGRID25828701 details
M3K7_MOUSETCAM2_MOUSEBioGRID25828701 details
M3K7_MOUSEAAPK2_MOUSEBioGRID20615388 details
M3K7_MOUSEAAPK1_MOUSEBioGRID20615388 details
M3K7_MOUSECYLD_MOUSEBioGRID29291351 details
M3K7_MOUSENOTC4_MOUSEBioGRID29228365 details