Entity Details

Primary name PLCG1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ62077
EntryNamePLCG1_MOUSE
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
TaxID10090
Evidenceevidence at protein level
Length1302
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPlcg1

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0001726 ruffle
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005158 insulin receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006816 calcium ion transport
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008180 COP9 signalosome
GO:0009306 protein secretion
GO:0009395 phospholipid catabolic process
GO:0010634 positive regulation of epithelial cell migration
GO:0016477 cell migration
GO:0019722 calcium-mediated signaling
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030136 clathrin-coated vesicle
GO:0030971 receptor tyrosine kinase binding
GO:0032959 inositol trisphosphate biosynthetic process
GO:0035254 glutamate receptor binding
GO:0042995 cell projection
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0046488 phosphatidylinositol metabolic process
GO:0050429 calcium-dependent phospholipase C activity
GO:0050804 modulation of chemical synaptic transmission
GO:0050852 T cell receptor signaling pathway
GO:0051219 phosphoprotein binding
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:1901339 regulation of store-operated calcium channel activity
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000353 positive regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell projection

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001452 SH3 domainDomainDomain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gammaFamilyFamily
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR028380 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1FamilyFamily
IPR035023 PLC-gamma, C-terminal SH2 domainDomainDomain
IPR035024 PLC-gamma, N-terminal SH2 domainDomainDomain
IPR035724 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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