Entity Details

Primary name DLG4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ62108
EntryNameDLG4_MOUSE
FullNameDisks large homolog 4
TaxID10090
Evidenceevidence at protein level
Length724
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDlg4

GO terms

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GOName
GO:0002091 negative regulation of receptor internalization
GO:0005102 signaling receptor binding
GO:0005109 frizzled binding
GO:0005198 structural molecule activity
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 chemical synaptic transmission
GO:0007626 locomotory behavior
GO:0008021 synaptic vesicle
GO:0008022 protein C-terminus binding
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016188 synaptic vesicle maturation
GO:0019865 immunoglobulin binding
GO:0019894 kinesin binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030054 cell junction
GO:0030165 PDZ domain binding
GO:0030425 dendrite
GO:0030863 cortical cytoskeleton
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031594 neuromuscular junction
GO:0031697 beta-1 adrenergic receptor binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0031748 D1 dopamine receptor binding
GO:0031812 P2Y1 nucleotide receptor binding
GO:0032281 AMPA glutamate receptor complex
GO:0032839 dendrite cytoplasm
GO:0033130 acetylcholine receptor binding
GO:0035176 social behavior
GO:0035254 glutamate receptor binding
GO:0035255 ionotropic glutamate receptor binding
GO:0035418 protein localization to synapse
GO:0035641 locomotory exploration behavior
GO:0035865 cellular response to potassium ion
GO:0042043 neurexin family protein binding
GO:0042220 response to cocaine
GO:0043005 neuron projection
GO:0043113 receptor clustering
GO:0043197 dendritic spine
GO:0044224 juxtaparanode region of axon
GO:0044300 cerebellar mossy fiber
GO:0044306 neuron projection terminus
GO:0044309 neuron spine
GO:0044877 protein-containing complex binding
GO:0045184 establishment of protein localization
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050806 positive regulation of synaptic transmission
GO:0050885 neuromuscular process controlling balance
GO:0060076 excitatory synapse
GO:0060997 dendritic spine morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0065003 protein-containing complex assembly
GO:0071625 vocalization behavior
GO:0071944 cell periphery
GO:0097060 synaptic membrane
GO:0097061 dendritic spine organization
GO:0097109 neuroligin family protein binding
GO:0097110 scaffold protein binding
GO:0097113 AMPA glutamate receptor clustering
GO:0097120 receptor localization to synapse
GO:0098609 cell-cell adhesion
GO:0098794 postsynapse
GO:0098839 postsynaptic density membrane
GO:0098919 structural constituent of postsynaptic density
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
GO:0098978 glutamatergic synapse
GO:0099031 anchored component of postsynaptic density membrane
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0150012 positive regulation of neuron projection arborization
GO:1904719 positive regulation of AMPA glutamate receptor clustering
GO:2000310 regulation of NMDA receptor activity
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000821 regulation of grooming behavior

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR008144 Guanylate kinase-like domainDomainDomain
IPR008145 Guanylate kinase/L-type calcium channel beta subunitDomainDomain
IPR016313 Disks large 1-likeFamilyFamily
IPR019583 PDZ-associated domain of NMDA receptorsDomainDomain
IPR019590 Disks large homologue 1, N-terminal PEST domainDomainDomain
IPR020590 Guanylate kinase, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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Interactions

67 interactions

InteractorPartnerSourcesPublicationsLink
DLG4_MOUSELRP2_MOUSEIntAct10827173 details
DLG4_MOUSELRP1_MOUSEBioGRID, IntAct10827173 19455133 23760271 27507650 28671696 details
DLG4_MOUSENMDZ1_MOUSEBioGRID, DIP, IntAct, MINT10862698 15663482 16554481 16601687 16635246 19240213 19243221 19455133 23760271 27507650 28671696 9647694 details
DLG4_MOUSENMDE2_MOUSEBioGRID, DIP, IntAct, MINT10862698 15663482 16332682 16554481 16635246 16710293 17950729 19240213 19243221 19455133 20141836 20467438 22234183 23760271 27507650 28671696 9647694 details
DLG4_MOUSEZDH17_HUMANIntAct15603740 details
DLG4_MOUSEFZD1_MOUSEMINT12067714 details
DLG4_MOUSEFZD2_MOUSEMINT12067714 details
DLG4_MOUSEFZD4_MOUSEMINT12067714 details
DLG4_MOUSEFZD7_MOUSEMINT12067714 details
DLG4_MOUSEKCNA4_MOUSEBioGRID, IntAct, MINT12067714 14559911 19455133 27507650 28671696 details
DLG4_MOUSENMDE1_MOUSEBioGRID, DIP, IntAct, MINT15663482 16332682 16554481 19240213 19243221 19455133 23760271 27507650 28671696 9647694 details
DLG4_MOUSENRCAM_MOUSEBioGRID, MINT16882004 details
DLG4_MOUSESSR1_MOUSEMINT17950729 details
DLG4_MOUSESSR4_MOUSEMINT17950729 details
DLG4_MOUSESSR2_MOUSEMINT17950729 details
DLG4_MOUSENMDE4_MOUSEBioGRID, IntAct19455133 27507650 28671696 9647694 details
DLG4_MOUSENETO1_MOUSEBioGRID, DIP, IntAct19243221 19455133 27507650 28671696 details
DLG4_MOUSENMDE3_MOUSEBioGRID, IntAct19455133 9647694 details
DLG4_MOUSENEB2_MOUSEBioGRID, IntAct20124353 28634551 28671696 30562941 details
DLG4_MOUSESQSTM_HUMANBioGRID17898222 details
DLG4_MOUSEP3C2A_MOUSEBioGRID20467438 details
DLG4_MOUSEARHG8_HUMANBioGRID17938206 details
DLG4_MOUSEMTR1A_HUMANBioGRID18448421 details
DLG4_MOUSEBAIP2_HUMANBioGRID15255944 details
DLG4_MOUSENMDZ1_HUMANBioGRID15255944 details
DLG4_MOUSESEM4B_MOUSEBioGRID, MINT15978582 32325033 details
DLG4_MOUSESEM4G_MOUSEMINT15978582 details
DLG4_MOUSESEM4C_MOUSEMINT15978582 details
DLG4_MOUSEAPC_HUMANMINT12067714 details
DLG4_MOUSELRFN2_MOUSEIntAct16495444 details
DLG4_MOUSEEXOC4_MOUSEMINT16601687 details
DLG4_MOUSEEXOC7_MOUSEMINT16601687 details
DLG4_MOUSELRP8_MOUSEIntAct16332682 details
DLG4_MOUSEMK01_MOUSEBioGRID, IntAct19455133 27507650 28671696 details
DLG4_MOUSENSF_MOUSEBioGRID, IntAct19455133 28671696 details
DLG4_MOUSEDLG2_MOUSEBioGRID, IntAct19455133 27507650 28671696 details
DLG4_MOUSEKCC2A_MOUSEBioGRID, IntAct19455133 27507650 28671696 details
DLG4_MOUSEBAIP2_MOUSEBioGRID, IntAct19455133 27507650 28671696 details
DLG4_MOUSEARC_MOUSEBioGRID, DIP, IntAct19455133 23424281 27507650 28671696 28804447 details
DLG4_MOUSEABLM1_MOUSEBioGRID, IntAct19455133 27507650 28671696 details
DLG4_MOUSEGUAD_MOUSEBioGRID, IntAct19022416 19455133 27507650 28671696 32325033 details
DLG4_MOUSENRX1A_MOUSEBioGRID, IntAct19455133 27507650 28671696 details
DLG4_MOUSERAC1_MOUSEBioGRID, IntAct19455133 27507650 28671696 details
DLG4_MOUSEDLG3_MOUSEBioGRID, IntAct19455133 27507650 28671696 32325033 details
DLG4_MOUSEDLG1_MOUSEBioGRID, IntAct19455133 27507650 28671696 32325033 details
DLG4_MOUSEA4_MOUSEMINT20573181 details
DLG4_MOUSEMTAP2_MOUSEMINT20573181 details
DLG4_MOUSESH3K1_MOUSEBioGRID, MINT20551902 details
DLG4_MOUSEMDM2_MOUSEBioGRID, IntAct21849563 23260144 30292394 details
DLG4_MOUSEERBB4_MOUSEDIP18385378 details
DLG4_MOUSENTRK2_MOUSEBioGRID, DIP23424281 details
DLG4_MOUSERHG32_MOUSEBioGRID, IntAct12531901 28671696 details
DLG4_MOUSECRFR1_MOUSEMINT26352593 details
DLG4_MOUSEAP2B1_MOUSEBioGRID21849563 details
DLG4_MOUSEHOME2_MOUSEBioGRID10493740 details
DLG4_MOUSEASIC2_MOUSEBioGRID19571134 details
DLG4_MOUSESEM4F_MOUSEBioGRID11483650 details
DLG4_MOUSEKCND2_MOUSEBioGRID14559911 details
DLG4_MOUSETHY1_MOUSEBioGRID14559911 details
DLG4_MOUSEAT1A1_MOUSEBioGRID14559911 details
DLG4_MOUSEALS2_MOUSEBioGRID17093100 details
DLG4_MOUSEAGRB1_MOUSEBioGRID23782696 details
DLG4_MOUSENRX1B_MOUSEBioGRID27507650 28671696 details
DLG4_MOUSEPTN5_MOUSEBioGRID27457929 details
DLG4_MOUSEDP13A_MOUSEBioGRID27300007 details
DLG4_MOUSEPDE10_MOUSEBioGRID25762721 details
DLG4_MOUSEHUWE1_MOUSEBioGRID30721695 details