Entity Details

Primary name JAK3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ62137
EntryNameJAK3_MOUSE
FullNameTyrosine-protein kinase JAK3
TaxID10090
Evidenceevidence at protein level
Length1100
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesJak3

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002731 negative regulation of dendritic cell cytokine production
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0030183 B cell differentiation
GO:0030218 erythrocyte differentiation
GO:0032693 negative regulation of interleukin-10 production
GO:0032695 negative regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0035771 interleukin-4-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0045087 innate immune response
GO:0045221 negative regulation of FasL production
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048535 lymph node development
GO:0050868 negative regulation of T cell activation
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051928 positive regulation of calcium ion transport
GO:0070232 regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070672 response to interleukin-15
GO:0071104 response to interleukin-9
GO:0071345 cellular response to cytokine stimulus
GO:2000670 positive regulation of dendritic cell apoptotic process
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cytoplasm
Endomembrane system

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020775 Tyrosine-protein kinase, non-receptor Jak3FamilyFamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR041046 JAK, FERM F2 lobe domainDomainDomain
IPR041155 FERM F1 lobe ubiquitin-like domainDomainDomain
IPR041381 Jak1, pleckstrin homology-like domainDomainDomain

Diseases

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