Entity Details

Primary name RO52_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ62191
EntryNameRO52_MOUSE
FullNameE3 ubiquitin-protein ligase TRIM21
TaxID10090
Evidenceevidence at protein level
Length470
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0000932 P-body
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0006513 protein monoubiquitination
GO:0007049 cell cycle
GO:0008270 zinc ion binding
GO:0010468 regulation of gene expression
GO:0010508 positive regulation of autophagy
GO:0016567 protein ubiquitination
GO:0019901 protein kinase binding
GO:0031410 cytoplasmic vesicle
GO:0031648 protein destabilization
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032092 positive regulation of protein binding
GO:0032880 regulation of protein localization
GO:0032897 negative regulation of viral transcription
GO:0034341 response to interferon-gamma
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0045787 positive regulation of cell cycle
GO:0045824 negative regulation of innate immune response
GO:0046596 regulation of viral entry into host cell
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070534 protein K63-linked ubiquitination
GO:0090086 negative regulation of protein deubiquitination
GO:1902187 negative regulation of viral release from host cell

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001870 B30.2/SPRY domainDomainDomain
IPR003877 SPRY domainDomainDomain
IPR003879 Butyrophylin-like, SPRY domainDomainDomain
IPR006574 SPRY-associatedDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR018957 Zinc finger, C3HC4 RING-typeDomainDomain
IPR020457 Zinc finger, B-box, chordataDomainDomain
IPR035831 TRIM21, PRY/SPRY domainDomainDomain
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
RO52_MOUSEDDX41_MOUSEInnateDB23222971 details