Entity Details

Primary name IRAK1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ62406
EntryNameIRAK1_MOUSE
FullNameInterleukin-1 receptor-associated kinase 1
TaxID10090
Evidenceevidence at protein level
Length710
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesIrak1

GO terms

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GOName
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005149 interleukin-1 receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007254 JNK cascade
GO:0016020 membrane
GO:0016301 kinase activity
GO:0019221 cytokine-mediated signaling pathway
GO:0031072 heat shock protein binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032481 positive regulation of type I interferon production
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034605 cellular response to heat
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060337 type I interferon signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0090370 negative regulation of cholesterol efflux
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell

Subcellular Location

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Subcellular Location
Cytoplasm
Lipid droplet
Nucleus

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR035533 Interleukin-1 receptor-associated kinase 1, death domainDomainDomain
IPR035536 Interleukin-1 receptor-associated kinase 1FamilyFamily

Diseases

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Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
IRAK1_MOUSETRAF6_MOUSEBioGRID, IntAct12566447 15102471 16831874 21460221 details
IRAK1_MOUSEMYD88_MOUSEBioGRID, DIP, InnateDB, IntAct10854325 15952741 21441935 21743479 22011580 30108181 31930677 details
IRAK1_MOUSEXIAP_MOUSEIntAct15102471 details
IRAK1_MOUSENOTC2_MOUSEIntAct15102471 details
IRAK1_MOUSEEEA1_MOUSEIntAct15102471 details
IRAK1_MOUSEPARVG_MOUSEIntAct15102471 details
IRAK1_MOUSELPXN_MOUSEIntAct15102471 details
IRAK1_MOUSEMDFIC_MOUSEIntAct15102471 details
IRAK1_MOUSES10AA_MOUSEIntAct15102471 details
IRAK1_MOUSEANR17_MOUSEIntAct15102471 details
IRAK1_MOUSEANXA1_MOUSEIntAct15102471 details
IRAK1_MOUSEDLK1_MOUSEIntAct15102471 details
IRAK1_MOUSEFBLN2_MOUSEIntAct15102471 details
IRAK1_MOUSEECH1_MOUSEIntAct15102471 details
IRAK1_MOUSEAASD1_MOUSEIntAct15102471 details
IRAK1_MOUSEDYLT1_MOUSEIntAct15102471 details
IRAK1_MOUSEVCIP1_MOUSEIntAct15102471 details
IRAK1_MOUSEDKK3_MOUSEIntAct15102471 details
IRAK1_MOUSEIRAK4_MOUSEBioGRID19378012 details
IRAK1_MOUSEPIN1_MOUSEBioGRID21743479 details
IRAK1_MOUSEPELI2_MOUSEBioGRID, IntAct12370331 details
IRAK1_MOUSETIFA_MOUSEIntAct12566447 details
IRAK1_MOUSETOLIP_MOUSEBioGRID, IntAct10854325 19273233 details
IRAK1_MOUSEIL1R1_MOUSEBioGRID, IntAct10854325 17507369 details
IRAK1_MOUSEPIN1_HUMANInnateDB21743479 details
IRAK1_MOUSEIRF5_MOUSEBioGRID, IntAct18824541 24706909 details
IRAK1_MOUSETRAF2_MOUSEIntAct24706909 details
IRAK1_MOUSEOSTP_MOUSEIntAct24706909 details
IRAK1_MOUSEUBB_MOUSEDIP19815506 details
IRAK1_MOUSEUBC_MOUSEDIP19815506 details
IRAK1_MOUSERS27A_MOUSEDIP19815506 details
IRAK1_MOUSERL40_MOUSEDIP19815506 details
IRAK1_MOUSETLR4_MOUSEBioGRID18562480 details
IRAK1_MOUSETNR1A_MOUSEBioGRID18562480 details
IRAK1_MOUSEIL1AP_MOUSEBioGRID18562480 details
IRAK1_MOUSEBCL10_MOUSEBioGRID16831874 details
IRAK1_MOUSEM3K7_MOUSEBioGRID16831874 details
IRAK1_MOUSEIRAK1_MOUSEBioGRID21460221 details
IRAK1_MOUSERSAD2_MOUSEBioGRID21435586 details
IRAK1_MOUSERNF41_MOUSEBioGRID19483718 details
IRAK1_MOUSESTAT3_MOUSEBioGRID15465816 details
IRAK1_MOUSEKPCE_MOUSEBioGRID20044140 details
IRAK1_MOUSENR0B2_MOUSEBioGRID19104650 details
IRAK1_MOUSELIT1_MOUSEBioGRID22037600 details
IRAK1_MOUSEFBW1A_MOUSEBioGRID29038250 details
IRAK1_MOUSERN152_HUMANBioGRID31930677 details