Entity Details

Primary name SMAD2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ62432
EntryNameSMAD2_MOUSE
FullNameMothers against decapentaplegic homolog 2
TaxID10090
Evidenceevidence at protein level
Length467
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesSmad2

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0001706 endoderm formation
GO:0001707 mesoderm formation
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007183 SMAD protein complex assembly
GO:0007352 zygotic specification of dorsal/ventral axis
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007492 endoderm development
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0009749 response to glucose
GO:0009791 post-embryonic development
GO:0009880 embryonic pattern specification
GO:0009952 anterior/posterior pattern specification
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0019902 phosphatase binding
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030073 insulin secretion
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0031016 pancreas development
GO:0031625 ubiquitin protein ligase binding
GO:0032444 activin responsive factor complex
GO:0032924 activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0034713 type I transforming growth factor beta receptor binding
GO:0035265 organ growth
GO:0035556 intracellular signal transduction
GO:0038092 nodal signaling pathway
GO:0042060 wound healing
GO:0045165 cell fate commitment
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048156 tau protein binding
GO:0048340 paraxial mesoderm morphogenesis
GO:0048589 developmental growth
GO:0048617 embryonic foregut morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0051098 regulation of binding
GO:0060039 pericardium development
GO:0060395 SMAD protein signal transduction
GO:0062009 secondary palate development
GO:0070410 co-SMAD binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0070723 response to cholesterol
GO:0071141 SMAD protein complex
GO:0071144 heteromeric SMAD protein complex
GO:0097718 disordered domain specific binding
GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001132 SMAD domain, Dwarfin-typeDomainDomain
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013019 MAD homology, MH1DomainDomain
IPR013790 DwarfinFamilyFamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR036578 SMAD MH1 domain superfamilyFamilyHomologous superfamily

Diseases

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