Entity Details

Primary name SYGP1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionF6SEU4
EntryNameSYGP1_MOUSE
FullNameRas/Rap GTPase-activating protein SynGAP
TaxID10090
Evidenceevidence at protein level
Length1340
SequenceStatuscomplete
DateCreated2011-12-14
DateModified2021-06-02

Ontological Relatives

GenesSyngap1

GO terms

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GOName
GO:0005096 GTPase activator activity
GO:0005886 plasma membrane
GO:0007265 Ras protein signal transduction
GO:0007389 pattern specification process
GO:0008542 visual learning
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016358 dendrite development
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0043113 receptor clustering
GO:0043198 dendritic shaft
GO:0043408 regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045202 synapse
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048167 regulation of synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050771 negative regulation of axonogenesis
GO:0050803 regulation of synapse structure or activity
GO:0098880 maintenance of postsynaptic specialization structure
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component

Subcellular Location

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Subcellular Location
Cell junction
Membrane

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR001936 Ras GTPase-activating domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR021887 Domain of unknown function DUF3498DomainDomain
IPR023152 Ras GTPase-activating protein, conserved siteSiteConserved site
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR037779 SynGAP, PH domainDomainDomain
IPR039360 Ras GTPase-activating proteinFamilyFamily

Diseases

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