Entity Details

Primary name LFTY1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ64280
EntryNameLFTY1_MOUSE
FullNameLeft-right determination factor 1
TaxID10090
Evidenceevidence at transcript level
Length368
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesLefty1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003007 heart morphogenesis
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007368 determination of left/right symmetry
GO:0008083 growth factor activity
GO:0008285 negative regulation of cell population proliferation
GO:0009948 anterior/posterior axis specification
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030509 BMP signaling pathway
GO:0032526 response to retinoic acid
GO:0038100 nodal binding
GO:0042074 cell migration involved in gastrulation
GO:0060395 SMAD protein signal transduction
GO:1900108 negative regulation of nodal signaling pathway
GO:1900124 negative regulation of nodal receptor complex assembly

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR003942 Left- Right determination factorFamilyFamily
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
LFTY1_MOUSETDGF1_MOUSEDIP14966532 details