Entity Details

Primary name ARF_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ64364
EntryNameARF_MOUSE
FullNameTumor suppressor ARF
TaxID10090
Evidenceevidence at protein level
Length169
SequenceStatuscomplete
DateCreated2005-10-11
DateModified2021-06-02

Ontological Relatives

GenesCdkn2a

GO terms

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GOName
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000422 autophagy of mitochondrion
GO:0001652 granular component
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006364 rRNA processing
GO:0006469 negative regulation of protein kinase activity
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007568 aging
GO:0007569 cell aging
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0008544 epidermis development
GO:0008637 apoptotic mitochondrial changes
GO:0009303 rRNA transcription
GO:0010243 response to organonitrogen compound
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0019789 SUMO transferase activity
GO:0019901 protein kinase binding
GO:0030308 negative regulation of cell growth
GO:0030889 negative regulation of B cell proliferation
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032091 negative regulation of protein binding
GO:0032991 protein-containing complex
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0033235 positive regulation of protein sumoylation
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0035019 somatic stem cell population maintenance
GO:0035985 senescence-associated heterochromatin focus
GO:0035986 senescence-associated heterochromatin focus assembly
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046825 regulation of protein export from nucleus
GO:0047485 protein N-terminus binding
GO:0048103 somatic stem cell division
GO:0050821 protein stabilization
GO:0051059 NF-kappaB binding
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051882 mitochondrial depolarization
GO:0055105 ubiquitin-protein transferase inhibitor activity
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0070301 cellular response to hydrogen peroxide
GO:0070534 protein K63-linked ubiquitination
GO:0090398 cellular senescence
GO:0090399 replicative senescence
GO:0097371 MDM2/MDM4 family protein binding
GO:0097718 disordered domain specific binding
GO:1900182 positive regulation of protein localization to nucleus
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1902510 regulation of apoptotic DNA fragmentation
GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process
GO:1903214 regulation of protein targeting to mitochondrion
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:1990000 amyloid fibril formation
GO:1990948 ubiquitin ligase inhibitor activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000346 negative regulation of hepatocyte proliferation
GO:2000435 negative regulation of protein neddylation
GO:2000774 positive regulation of cellular senescence

Subcellular Location

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Subcellular Location
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR010868 Tumor suppressor ARFFamilyFamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
ARF_MOUSEPP1A_MOUSEBioGRID, IntAct17274640 details
ARF_MOUSEPP1G_MOUSEBioGRID, IntAct17274640 details
ARF_MOUSEPEX19_HUMANBioGRID, UniProt11259404 12154087 12581788 details
ARF_MOUSEPEX19_MOUSEBioGRID, UniProt11259404 16582619 details
ARF_MOUSEMDM2_MOUSEBioGRID, IntAct10713175 15485902 20832751 22378045 23580573 details
ARF_MOUSEMDM2_HUMANBioGRID10713175 11718560 details
ARF_MOUSETBRG1_MOUSEBioGRID16582619 17110379 details
ARF_MOUSEERF3A_MOUSEBioGRID16582619 details
ARF_MOUSEZFP91_MOUSEBioGRID16582619 details
ARF_MOUSEHS90B_MOUSEBioGRID16582619 details
ARF_MOUSERABL6_MOUSEBioGRID16582619 details
ARF_MOUSEEIF3A_MOUSEBioGRID16582619 details
ARF_MOUSERL9_MOUSEBioGRID16582619 details
ARF_MOUSERS7_MOUSEBioGRID16582619 details
ARF_MOUSENEB2_MOUSEBioGRID16582619 details
ARF_MOUSEOSTP_MOUSEBioGRID16582619 details
ARF_MOUSETBA1A_MOUSEBioGRID16582619 details
ARF_MOUSETPIS_MOUSEBioGRID16582619 details
ARF_MOUSECARF_HUMANBioGRID12154087 12581788 details
ARF_MOUSEZN235_MOUSEBioGRID16582619 details
ARF_MOUSEUBC_MOUSEBioGRID28190767 details
ARF_MOUSEC1QBP_HUMANUniProt17486078 details
ARF_MOUSEMTA1_MOUSEDIP21555589 details
ARF_MOUSESP1_MOUSEBioGRID, DIP21555589 details
ARF_MOUSENPM_HUMANBioGRID, DIP, IntAct16540653 17277230 23851489 details
ARF_MOUSENPM2_HUMANIntAct16540653 details
ARF_MOUSEHUWE1_MOUSEBioGRID22754359 details
ARF_MOUSEBCL6_MOUSEBioGRID15567177 details
ARF_MOUSEP53_MOUSEBioGRID10706102 15989966 9653180 details
ARF_MOUSENPM_MOUSEBioGRID15485902 details
ARF_MOUSEMYC_MOUSEBioGRID15361884 details
ARF_MOUSEMAX_MOUSEBioGRID15361884 details
ARF_MOUSEB2CL1_MOUSEBioGRID19049976 details
ARF_MOUSECARF_MOUSEBioGRID12154087 details