Entity Details

Primary name ATP7B_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ64446
EntryNameATP7B_MOUSE
FullNameCopper-transporting ATPase 2
TaxID10090
Evidenceevidence at protein level
Length1462
SequenceStatuscomplete
DateCreated2000-12-08
DateModified2021-06-02

Ontological Relatives

GenesAtp7b

GO terms

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GOName
GO:0005375 copper ion transmembrane transporter activity
GO:0005507 copper ion binding
GO:0005524 ATP binding
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0006825 copper ion transport
GO:0006878 cellular copper ion homeostasis
GO:0006882 cellular zinc ion homeostasis
GO:0007595 lactation
GO:0008270 zinc ion binding
GO:0015677 copper ion import
GO:0015680 protein maturation by copper ion transfer
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0032588 trans-Golgi network membrane
GO:0043682 P-type divalent copper transporter activity
GO:0045177 apical part of cell
GO:0046688 response to copper ion
GO:0048471 perinuclear region of cytoplasm
GO:0051208 sequestering of calcium ion
GO:0060003 copper ion export
GO:0070160 tight junction
GO:0071280 cellular response to copper ion
GO:0140581 P-type monovalent copper transporter activity

Subcellular Location

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Subcellular Location
Golgi apparatus
Late endosome

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR006121 Heavy metal-associated domain, HMADomainDomain
IPR006122 Heavy metal-associated domain, copper ion-bindingDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR017969 Heavy-metal-associated, conserved siteSiteConserved site
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR027256 P-type ATPase, subfamily IBFamilyFamily
IPR036163 Heavy metal-associated domain superfamilyFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ATP7B_MOUSECLUS_MOUSEBioGRID21242307 details