Entity Details

Primary name TOP2B_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ64511
EntryNameTOP2B_MOUSE
FullNameDNA topoisomerase 2-beta
TaxID10090
Evidenceevidence at protein level
Length1612
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesTop2b

GO terms

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GOName
GO:0000712 resolution of meiotic recombination intermediates
GO:0000819 sister chromatid segregation
GO:0001764 neuron migration
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006265 DNA topological change
GO:0007409 axonogenesis
GO:0007569 cell aging
GO:0008022 protein C-terminus binding
GO:0019899 enzyme binding
GO:0030900 forebrain development
GO:0042826 histone deacetylase binding
GO:0043021 ribonucleoprotein complex binding
GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0070301 cellular response to hydrogen peroxide
GO:0071318 cellular response to ATP
GO:1990904 ribonucleoprotein complex
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001241 DNA topoisomerase, type IIAFamilyFamily
IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminalDomainDomain
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR006171 TOPRIM domainDomainDomain
IPR012542 DTHCTDomainDomain
IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2DomainDomain
IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-betaFamilyHomologous superfamily
IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminalFamilyHomologous superfamily
IPR013760 DNA topoisomerase, type IIA-like domain superfamilyFamilyHomologous superfamily
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR018522 DNA topoisomerase, type IIA, conserved siteSiteConserved site
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR028467 DNA topoisomerase II-betaFamilyFamily
IPR031660 C-terminal associated domain of TOPRIMDomainDomain
IPR034157 DNA topoisomerase 2, TOPRIM domainDomainDomain
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TOP2B_MOUSEAICDA_MOUSEInnateDB21186367 details
TOP2B_MOUSEUHRF1_MOUSEBioGRID25451918 details