Entity Details

Primary name SMCA2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ6DIC0
EntryNameSMCA2_MOUSE
FullNameProbable global transcription activator SNF2L2
TaxID10090
Evidenceevidence at protein level
Length1577
SequenceStatuscomplete
DateCreated2010-02-09
DateModified2021-06-02

Ontological Relatives

GenesSmarca2

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0007399 nervous system development
GO:0008094 ATPase, acting on DNA
GO:0008285 negative regulation of cell population proliferation
GO:0016514 SWI/SNF complex
GO:0030308 negative regulation of cell growth
GO:0035887 aortic smooth muscle cell differentiation
GO:0042393 histone binding
GO:0043044 ATP-dependent chromatin remodeling
GO:0043231 intracellular membrane-bounded organelle
GO:0045111 intermediate filament cytoskeleton
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0061484 hematopoietic stem cell homeostasis
GO:0070615 nucleosome-dependent ATPase activity
GO:0071564 npBAF complex
GO:0071565 nBAF complex

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000330 SNF2, N-terminalDomainDomain
IPR001487 BromodomainDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR006576 BRK domainDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014012 Helicase/SANT-associated domainDomainDomain
IPR014978 Glutamine-Leucine-Glutamine, QLQDomainDomain
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029295 Snf2, ATP coupling domainDomainDomain
IPR030088 SWI/SNF complex subunit SMARCA2FamilyFamily
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR037259 BRK domain superfamilyFamilyHomologous superfamily
IPR038718 SNF2-like, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
SMCA2_MOUSESMRD1_MOUSEBioGRID11053448 19279220 details
SMCA2_MOUSESMRC1_MOUSEBioGRID, MINT19279220 24421395 details
SMCA2_MOUSEJUN_HUMANBioGRID11053448 details
SMCA2_MOUSEJUN_MOUSEBioGRID11053448 details
SMCA2_MOUSEFOS_MOUSEBioGRID11053448 details
SMCA2_MOUSENR0B2_MOUSEBioGRID19805516 details
SMCA2_MOUSENANOG_MOUSEBioGRID18454139 details
SMCA2_MOUSECREST_MOUSEBioGRID19279220 details
SMCA2_MOUSESFPQ_MOUSEBioGRID19279220 details
SMCA2_MOUSENUMA1_MOUSEBioGRID19279220 details
SMCA2_MOUSENONO_MOUSEBioGRID19279220 details
SMCA2_MOUSEMBB1A_MOUSEBioGRID19279220 details
SMCA2_MOUSESRRM2_MOUSEBioGRID19279220 details
SMCA2_MOUSEBRD9_MOUSEBioGRID19279220 details
SMCA2_MOUSEBRD7_MOUSEBioGRID19279220 details
SMCA2_MOUSEBCL7A_MOUSEBioGRID19279220 details
SMCA2_MOUSEBICRA_MOUSEBioGRID19279220 details
SMCA2_MOUSEACTG_MOUSEBioGRID19279220 details
SMCA2_MOUSEACL6A_MOUSEBioGRID19279220 32325033 details
SMCA2_MOUSESNF5_MOUSEBioGRID19279220 details
SMCA2_MOUSESMCE1_MOUSEBioGRID19279220 details
SMCA2_MOUSESMRD3_MOUSEBioGRID19279220 details
SMCA2_MOUSESMRC2_MOUSEBioGRID19279220 32325033 details
SMCA2_MOUSEARID2_MOUSEBioGRID19279220 details
SMCA2_MOUSEARI1B_MOUSEBioGRID17255939 19279220 details
SMCA2_MOUSESMCA4_MOUSEBioGRID19279220 details
SMCA2_MOUSEACL6B_MOUSEBioGRID12368262 details
SMCA2_MOUSEBRCA1_MOUSEBioGRID15574597 details
SMCA2_MOUSEARI1A_MOUSEBioGRID17255939 32325033 details
SMCA2_MOUSEMYSM1_MOUSEBioGRID22169041 details
SMCA2_MOUSECEBPA_MOUSEBioGRID15107404 details
SMCA2_MOUSEADNP_MOUSEBioGRID24489906 details