Entity Details

Primary name BCR_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ6PAJ1
EntryNameBCR_MOUSE
FullNameBreakpoint cluster region protein
TaxID10090
Evidenceevidence at protein level
Length1270
SequenceStatuscomplete
DateCreated2007-01-23
DateModified2021-06-02

Ontological Relatives

GenesBcr

GO terms

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GOName
GO:0002692 negative regulation of cellular extravasation
GO:0003014 renal system process
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007264 small GTPase mediated signal transduction
GO:0007420 brain development
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0019899 enzyme binding
GO:0030036 actin cytoskeleton organization
GO:0030216 keratinocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0030424 axon
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0035023 regulation of Rho protein signal transduction
GO:0042472 inner ear morphogenesis
GO:0043114 regulation of vascular permeability
GO:0043197 dendritic spine
GO:0043314 negative regulation of neutrophil degranulation
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0048872 homeostasis of number of cells
GO:0050728 negative regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050804 modulation of chemical synaptic transmission
GO:0050885 neuromuscular process controlling balance
GO:0051171 regulation of nitrogen compound metabolic process
GO:0051726 regulation of cell cycle
GO:0060216 definitive hemopoiesis
GO:0060268 negative regulation of respiratory burst
GO:0060313 negative regulation of blood vessel remodeling
GO:0065002 intracellular protein transmembrane transport
GO:0071222 cellular response to lipopolysaccharide
GO:0090630 activation of GTPase activity
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000378 negative regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cell junction
Cell projection

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000198 Rho GTPase-activating protein domainDomainDomain
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR015123 Bcr-Abl oncoprotein oligomerisationDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036481 Bcr-Abl oncoprotein oligomerisation domain superfamilyFamilyHomologous superfamily
IPR037769 Abr/BcrFamilyFamily

Diseases

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