Entity Details

Primary name KMT2D_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ6PDK2
EntryNameKMT2D_MOUSE
FullNameHistone-lysine N-methyltransferase 2D
TaxID10090
Evidenceevidence at protein level
Length5588
SequenceStatuscomplete
DateCreated2010-11-30
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000976 transcription cis-regulatory region binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001555 oocyte growth
GO:0001701 in utero embryonic development
GO:0003713 transcription coactivator activity
GO:0005654 nucleoplasm
GO:0006342 chromatin silencing
GO:0008284 positive regulation of cell population proliferation
GO:0010468 regulation of gene expression
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0035097 histone methyltransferase complex
GO:0042393 histone binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0043627 response to estrogen
GO:0044648 histone H3-K4 dimethylation
GO:0044666 MLL3/4 complex
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048477 oogenesis
GO:0051568 histone H3-K4 methylation
GO:0080182 histone H3-K4 trimethylation
GO:0097692 histone H3-K4 monomethylation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001214 SET domainDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR003616 Post-SET domainDomainDomain
IPR003888 FY-rich, N-terminalDomainDomain
IPR003889 FY-rich, C-terminalDomainDomain
IPR009071 High mobility group box domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR034732 Extended PHD (ePHD) domainDomainDomain
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily
IPR037890 Histone-lysine N-methyltransferase 2DFamilyFamily
IPR041961 KMT2D, ePHD1 domainDomainDomain
IPR041964 KMT2D, ePHD2 domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
KMT2D_MOUSEASH2L_HUMANIntAct16603732 details