Entity Details

Primary name CAN2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO08529
EntryNameCAN2_MOUSE
FullNameCalpain-2 catalytic subunit
TaxID10090
Evidenceevidence at protein level
Length700
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCapn2

GO terms

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GOName
GO:0000785 chromatin
GO:0001666 response to hypoxia
GO:0001824 blastocyst development
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0007520 myoblast fusion
GO:0007565 female pregnancy
GO:0008092 cytoskeletal protein binding
GO:0008233 peptidase activity
GO:0009897 external side of plasma membrane
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016020 membrane
GO:0016540 protein autoprocessing
GO:0019899 enzyme binding
GO:0030425 dendrite
GO:0031143 pseudopodium
GO:0032675 regulation of interleukin-6 production
GO:0035458 cellular response to interferon-beta
GO:0042542 response to hydrogen peroxide
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0048266 behavioral response to pain
GO:0051493 regulation of cytoskeleton organization
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071230 cellular response to amino acid stimulus
GO:0097038 perinuclear endoplasmic reticulum
GO:1901216 positive regulation of neuron death
GO:1901741 positive regulation of myoblast fusion
GO:2001247 positive regulation of phosphatidylcholine biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR001300 Peptidase C2, calpain, catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR022682 Peptidase C2, calpain, large subunit, domain IIIDomainDomain
IPR022683 Peptidase C2, calpain, domain IIIDomainDomain
IPR022684 Peptidase C2, calpain familyFamilyFamily
IPR029539 Calpain-2FamilyFamily
IPR033883 Calpain subdomain IIIDomainDomain
IPR036213 Calpain large subunit, domain III superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR042736 CAPN2, penta-EF hand, calcium binding motifDomainDomain

Diseases

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Interactions

4 interactions