Entity Details

Primary name ESR2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO08537
EntryNameESR2_MOUSE
FullNameEstrogen receptor beta
TaxID10090
Evidenceevidence at protein level
Length530
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesEsr2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001541 ovarian follicle development
GO:0001662 behavioral fear response
GO:0001764 neuron migration
GO:0003677 DNA binding
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005496 steroid binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007420 brain development
GO:0007611 learning or memory
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0019899 enzyme binding
GO:0030284 estrogen receptor activity
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0032993 protein-DNA complex
GO:0033574 response to testosterone
GO:0034056 estrogen response element binding
GO:0042127 regulation of cell population proliferation
GO:0042562 hormone binding
GO:0042802 identical protein binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043204 perikaryon
GO:0043523 regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044849 estrous cycle
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048471 perinuclear region of cytoplasm
GO:0048521 negative regulation of behavior
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060011 Sertoli cell proliferation
GO:0060065 uterus development
GO:0060068 vagina development
GO:0060548 negative regulation of cell death
GO:0060740 prostate gland epithelium morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071392 cellular response to estradiol stimulus
GO:1901215 negative regulation of neuron death
GO:1990841 promoter-specific chromatin binding
GO:2000252 negative regulation of feeding behavior
GO:2000378 negative regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR021064 Estrogen receptor beta, N-terminalDomainDomain
IPR024178 Estrogen receptor/oestrogen-related receptorFamilyFamily
IPR028355 Estrogen receptor beta/gammaFamilyFamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions