Entity Details

Primary name DDX58_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ6Q899
EntryNameDDX58_MOUSE
FullNameAntiviral innate immune response receptor RIG-I
TaxID10090
Evidenceevidence at protein level
Length926
SequenceStatuscomplete
DateCreated2005-11-08
DateModified2021-06-02

Ontological Relatives

GenesDdx58

GO terms

Show/Hide Table
GOName
GO:0002230 positive regulation of defense response to virus by host
GO:0002735 positive regulation of myeloid dendritic cell cytokine production
GO:0003690 double-stranded DNA binding
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0008270 zinc ion binding
GO:0009597 detection of virus
GO:0009615 response to virus
GO:0010628 positive regulation of gene expression
GO:0015629 actin cytoskeleton
GO:0016787 hydrolase activity
GO:0030334 regulation of cell migration
GO:0031625 ubiquitin protein ligase binding
GO:0032587 ruffle membrane
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0039529 RIG-I signaling pathway
GO:0042802 identical protein binding
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051607 defense response to virus
GO:0060760 positive regulation of response to cytokine stimulus
GO:0071360 cellular response to exogenous dsRNA
GO:0140374 antiviral innate immune response
GO:1990904 ribonucleoprotein complex

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR006935 Helicase/UvrB, N-terminalDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR021673 RIG-I-like receptor, C-terminal regulatory domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031964 Caspase recruitment domainDomainDomain
IPR038557 RIG-I-like receptor, C-terminal domain superfamilyFamilyHomologous superfamily
IPR041204 RIG-I receptor, C-terminalDomainDomain
IPR042145 RIG-I, CARD domain repeat 2DomainDomain

Diseases

Show/Hide Table